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HEXA-LACTOSIDE-TRIAZANONANE TRIACETIC ACID (NOTA) DERIVATIVE, METHOD FOR RADIOLABELING HEXA-LACTOSIDE POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENT FOR LIVER RECEPTOR WITH GA-68, AND HEXA-LACTOSIDE PET IMAGING AGENT FOR LIVER RECEPTOR
HEXA-LACTOSIDE-TRIAZANONANE TRIACETIC ACID (NOTA) DERIVATIVE, METHOD FOR RADIOLABELING HEXA-LACTOSIDE POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENT FOR LIVER RECEPTOR WITH GA-68, AND HEXA-LACTOSIDE PET IMAGING AGENT FOR LIVER RECEPTOR
The present invention provides a hexa-lactoside-triazanonane triacetic acid (NOTA) derivative, a method for radiolabeling a hexa-lactoside positron emission tomography (PET) imaging agent for a liver receptor with Ga-68, and a hexa-lactoside PET imaging agent for a liver receptor. The hexa-lactoside-NOTA derivative is a conjugate of six chains of lactose with NOTA obtained by conjugating hexa-lactoside to a chelating agent p-thiocyanate-benzyl-triazanonane diacetic acid-glutamic acid in the presence of triethyl amine/dimethyl formamide as a solvent. The radiolabeling method comprises labeling with Ga-68 at room temperature. According to the present invention, the labeling effect is stable, the labeling efficiency of the labeled product is greater than 95%, the labeled product is highly stable and the radiochemical purity is still greater than 90% after 4 hours.
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