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GLYCATED HEMOGLOBIN OXIDASE VARIANT AND METHOD FOR MEASUREMENT
GLYCATED HEMOGLOBIN OXIDASE VARIANT AND METHOD FOR MEASUREMENT
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机译:糖化血红蛋白氧化酶变异体和测量方法
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摘要
Provided is a glycated hemoglobin oxidase with small measurement error or without deviation of the measured value from the true value regarding a sample containing glycated abnormal hemoglobin. Provided are a glycated hemoglobin oxidase comprising an amino acid sequence in which the amino acid at the position corresponding to position 113, 109, 106, or 102 of the amino acid sequence of SEQ ID NO: 1 is substituted with an amino acid other than a positively-charged amino acid, such as glutamic acid, alanine, or aspartic acid as well as a method and a reagent kit for measurement of glycated hemoglobin using such glycated hemoglobin oxidase. The glycated hemoglobin is capable of reacting with various genotypes and enables highly accurate measurement of glycated hemoglobin in a sample containing glycated abnormal hemoglobin.
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机译:对于含有糖化异常血红蛋白的样品,提供了一种测量误差小或测量值与真实值没有偏差的糖化血红蛋白氧化酶。提供了一种糖化血红蛋白氧化酶,其包含氨基酸序列,其中与SEQ ID NO:1的氨基酸序列的113、109、106或102位相对应的氨基酸被α1以外的氨基酸取代。带正电荷的氨基酸,例如谷氨酸,丙氨酸或天冬氨酸,以及使用这种糖化血红蛋白氧化酶测量糖化血红蛋白的方法和试剂盒。糖化血红蛋白能够与各种基因型反应,并且能够高精度地测量包含糖化异常血红蛋白的样品中的糖化血红蛋白。
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