CHEMICAL INHIBITION OF THE E3 LIGASE SUBUNIT FBXO7 CONFERS NEUROPROTECTION AND ANTI-INFLAMMATORY ACTIVITY BY STABILIZING MITOCHONDRIA

摘要

A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II:; ;wherein each of R³-R⁷ is independently H, halogen, optionally-substituted alkyl, amino, alkoxy or hydroxy;R⁸ is an optionally-substituted heterocycloalkyl; anda is 0 to 3.