首页> 外国专利> COLLAGEN-BASED MENISCUS IMPLANTS

COLLAGEN-BASED MENISCUS IMPLANTS

机译:胶原蛋白的Meniscus植入物

摘要

A method for producing a collagen meniscus implant by obtaining a freshly excised non-human meniscus, rinsing it in an aqueous solution, drying the rinsed meniscus, shaping it to approximate in dimension an average-sized human meniscus, extracting non-collagenous material from the shaped meniscus, cross-linking, and sterilizing it, yielding a collagen meniscus implant containing at least 90% by weight of type I collagen, less than 0.5% by weight of native glycosaminoglycan, and less than 600 ppm DNA. Also disclosed is a collagen meniscus implant prepared by the above method. Further provided is a biocompatible and bioresorbable porous implant for meniscus repair. The implant includes a three-dimensional network of collagen fibers oriented in a direction approximating the collagen fiber orientation of a human meniscus. The implant has a size and a contour substantially equivalent to a human meniscus, and has a chemical composition similar to the above-described collagen meniscus implant.
机译:一种制备胶原半月板植入物的方法,该方法是通过获得新鲜切除的非人半月板,将其在水溶液中漂洗,干燥漂洗后的半月板,使其成形为近似尺寸的人半月板,然后从中提取非胶原材料。将半月板成形,交联并灭菌,得到的胶原半月板植入物包含至少90%重量的I型胶原,少于0.5%的天然糖胺聚糖和少于600 ppm的DNA。还公开了通过上述方法制备的胶原半月板植入物。还提供了用于弯液面修复的生物相容性和生物可吸收性的多孔植入物。植入物包括胶原纤维的三维网络,其定向在接近人半月板的胶原纤维取向的方向上。该植入物的大小和轮廓基本上与人类半月板相等,并且具有与上述胶原半月板植入物相似的化学组成。

著录项

  • 公开/公告号US2020038193A1

    专利类型

  • 公开/公告日2020-02-06

    原文格式PDF

  • 申请/专利权人 COLLAGEN MATRIX INC.;

    申请/专利号US201916597181

  • 申请日2019-10-09

  • 分类号A61F2/38;A61L27/36;A61F2/08;A61L27/54;

  • 国家 US

  • 入库时间 2022-08-21 11:19:29

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号