collection selection method, methods for determining amino acid sequences and for producing a cvp or collection of nucleic acids, cvp, collections of vaccine peptides, nucleic acids, one or more expression vectors, and collection of vector vectors expression

摘要

the present invention relates to a method of selecting a collection of peptides originated by changing the reading phase (cfsps) to produce a universal vaccine (cvp) peptide collection against cancer for prophylaxis and treatment of patients with hereditary and sporadic tumors with microsatellite instability (msi). this invention also concerns a method of producing a cvp, selecting a subset of reading-phase-changing peptides (fsps) from cfsp and optionally modifying the amino acid sequence (aa) of fsp to generate modified fsps (mfsps ). the invention also relates to collections of nucleic acids that encode a cvp of fsps and / or mfsps in one or more vaccine vectors that can be used simultaneously. these cvps, nucleic acids and vectors are used for the prophylaxis or treatment of cancers with msi.