首页> 外国专利> COMPOUND, MULTIMETER, VECTORIZED COMPOUND, COMPLEX OF THE REFERRED COMPOUND, AS WELL AS PHARMACEUTICAL, PHARMACEUTICAL COMPOSITIONS, AND LIPID DIAGNOSIS FOR MAGNETIC RESONANCE IMAGIOLOGY AND PROCESS FOR THE PREPARATION OF A METALLIC COMPLEX

COMPOUND, MULTIMETER, VECTORIZED COMPOUND, COMPLEX OF THE REFERRED COMPOUND, AS WELL AS PHARMACEUTICAL, PHARMACEUTICAL COMPOSITIONS, AND LIPID DIAGNOSIS FOR MAGNETIC RESONANCE IMAGIOLOGY AND PROCESS FOR THE PREPARATION OF A METALLIC COMPLEX

机译:复合,多价,矢量化复合物,所引用化合物的复合物,以及用于磁共振成像的药理学,药物诊断和脂类诊断,以及制备金属络合物的方法

摘要

b compounds comprising short chains of amino-alcohols and metal complexes for medical imaging d the present invention relates to compounds of formula (il) chosen from (lia) and (llb) or formula (vi) chosen from (via) and (vlb) of the following general formulas: where: x ~ 1 ~, x ~ 2 ~, x ~ 3 ~, x ~ 4 ~ ex ~ 5 ~ represent, independently of each other, ly where l represents a c ~ 1 ~ -c ~ 3 ~ alkyl group, preferably (ch ~ 2 ~) with n = 1 to 3, y represents -conh ~ 2 ~, -co-nr7r8 or -nr7-co-r8, or an isomer , an enantiomer or diastereoisomer of the same or mixtures thereof, or a pharmaceutically acceptable salt of the compounds of formula (route) and (vib). it also refers to a complex of these compounds with a paramagnetic metal or radionuclide and their use in diagnostic methods.
机译:包含用于医学成像的氨基醇和金属配合物的短链的化合物本发明涉及选自(lia)和(IIb)的式(il)或选自(via)的式(vi)的化合物和(vlb)的以下通式:其中:x〜1〜,x〜2〜,x〜3〜,x〜4〜ex〜5〜彼此独立地表示ly其中,l表示ac〜1〜 -c〜3〜烷基,优选(ch〜2〜),n = 1-3,y表示-conh〜2〜,-co-nr7r8或-nr7-co-r8,或异构体,对映异构体或非对映异构体相同或它们的混合物,或式(途径)和(vib)的化合物的药学上可接受的盐。它也指这些化合物与顺磁性金属或放射性核素的复合物,及其在诊断方法中的用途。

著录项

  • 公开/公告号BRPI0617151B1

    专利类型

  • 公开/公告日2020-08-11

    原文格式PDF

  • 申请/专利权人 GUERBET;

    申请/专利号BR2006PI17151

  • 发明设计人 MARC PORT;

    申请日2006-10-09

  • 分类号A61K51/04;C07C211/05;C07D257/02;C07D487/04;

  • 国家 BR

  • 入库时间 2022-08-21 11:18:14

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号