APPLICATION OF ANTIBODIES AND ANTIBODIES ANTIBODIES AGAINST CGRP FOR PREVENTION OR INHIBITION OF LIGHT PERFORMANCE OR RETURN TO LIGHT IN SUBJECTS NEEDING THIS, ESPECIALLY SUFFICIENT OF MIGRAIN

摘要

The present invention is directed to methods of inhibiting or preventing photophobia in patients in need thereof using antibodies or anti-CGRP antibody fragments that inhibit photophobia, especially CGRP-associated photophobia. These antibodies and fragments can be used to treat various disorders associated with photophobia, such as migraine, cluster headaches, etc. The present invention also provides assays using rodents that are transgenic for nestin / Ramp1, using a behavioral model of CGRP-mediated aversion to light to identify therapeutically effective antibodies against CGRP and fragments thereof that have specificity for binding to CGRP, inhibiting or preventing photophobia in subjects requiring this one. More specifically, the present invention is directed to methods for identifying therapeutically effective antibodies and fragments thereof having CGRP binding specificity that can be used to treat CGRP-associated disorders, for example, migraine. More specifically, the present invention relates to assays and methods of treatment using the antibodies described herein to inhibit or prevent photophobia, and their binding fragments, including the V, V and CDR polypeptide sequences described herein and polynucleotides encoding them.