An improved process for the preparation of linezolid

摘要

A process for the preparation of compound of Formula (I) comprising the steps of: a) reacting the compound of Formula (III) with (S)-Glycidylphthalimide of Formula (IX) in the presence of a metal hydride at a temperature of 50-60ºC is maintained for about 2-3 hours to give the compound of Formula (VI) wherein R represents hydrogen, C1-C5 alkyl, aryl or aralkyl; b) treating the compound of Formula (VI) with aqueous methyl amine or hydrazine hydrate, c) acylating the product of step b) with an acetylating agent, and d) isolating the compound of Formula (I).