Indazol compounds as m-glur4 Western Sahara enhancers, components and treatment of neurological disorders

摘要

A formula compound I, in which a is A1, A2 or A3; each R1 is independent and selected from h, D, oh, NH2, NR3, etc.; each R2 is optional and independently selected from h, D, oh, CONH2, NH2, etc.; R3 and R4 are independent h, asphalt, alcoxi or Oh; R5 is h or aspha R6 is h, CH3O, CD3; R7 is or I am me!R8 is a link, a-It's justAmong other things, R9 is either replaced or not replaced, or is selected from class h, abiotic, arilo, etc.; class n is 0-6; or a pharmacologically acceptable salt or its derivative is selected. These compounds are derived from indazol and act as metabolite receptors for Western Sahara enhancer / Western Sahara transformer positive, methyl glutamate 4 (mGluR4). It also mentions a pharmacological composition, preparation of the synthesis of these compounds, and a treatment for nerve conduction disorders and other diseases associated with mGluR4 activity, such as neurological and psychiatric disorders.