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Method of obtaining dressing materials for use in the treatment of diabetic foot wounds and dressing materials obtained by this method

机译:获得用于治疗糖尿病足伤口的敷料的方法以及通过该方法获得的敷料

摘要

The purpose of the notification is how to obtain dressings for the treatment of diabetic foot injuries and dressings obtained in this way. This means that a polyacrylonitrile solution containing silver nanoparticles is prepared to receive a prophylactic dressing by adding 20-30-nm-diameter 3% silver nanoparticles to the dimethylsfultolene and dispersing by ultrasonic homogeniser for a period of five minutes. After the solution has been obtained, it is supplemented with a granulated polyacrylonitrile and left to be completely dissolved for a period of 24h, resulting in the total concentration of the solution at level 7%,and then the solution is introduced into the chamber of the device to be transformed into micro and nano-fibers in an electrostatic field and subject to process conditions of 1 kV/cm, 1 ml/h, at eye temperature. 25oC, having obtained an antimicrobial material from which a shape of a certain size is cut and joins together in such a way as to surround the entire foot surface with material. constructed of four essential and interconnected layers,it is constructed of hydrophobic microfibres and/or a net to prevent adherence to the surface of the tissue of the first layer, placed above it a second layer with different properties and sometimes influences dependent on the introduced antimicrobial, antioxidative, angiogenic and a painkiller layer of a third layer of microfibres containing a water binding agent and finally a fourth layer of nanofibres with protective properties against mechanical agents and protection against microorganisms originating from the outside world.
机译:该通知的目的是如何获得用于治疗糖尿病足损伤的敷料以及以这种方式获得的敷料。这意味着,通过将直径为20-30 nm的3%银纳米颗粒添加到二甲基富勒烯中并通过超声均化器分散五分钟,来制备含有银纳米颗粒的聚丙烯腈溶液以接受预防性敷料。获得溶液后,向其中加入粒状聚丙烯腈,使其完全溶解24h,使溶液的总浓度为7%,然后将溶液引入到反应室中。该设备将在静电场中转变为微纤维和纳米纤维,并在眼温下经受1 kV / cm,1 ml / h的处理条件。在25℃下,获得一种抗菌材料,从该抗菌材料上切出一定尺寸的形状,并以材料包围整个脚表面的方式结合在一起。由四个基本且相互连接的层构成,它由疏水性微纤维和/或网构成,以防止粘附到第一层组织的表面,在其上方放置第二层,该第二层具有不同的特性,有时取决于所引入的抗菌剂层是含有水结合剂的第三层微纤维的抗氧化,抗血管生成和止痛剂层,最后是第四层纳米纤维,具有抗机械剂的保护性能和对外界微生物的保护。

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