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HOMOGENEOUS AQUEOUS SOLUTION OF INJECTABLE CHITOSAN HAVING A PH CLOSE TO PHYSIOLOGICAL PH
HOMOGENEOUS AQUEOUS SOLUTION OF INJECTABLE CHITOSAN HAVING A PH CLOSE TO PHYSIOLOGICAL PH
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机译:pH接近生理pH的可注射壳聚糖的均相水溶液
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摘要
The present invention relates to a homogeneous aqueous solution of injectable chitosan containing, in a physiologically acceptable medium, between 0.1 and 4.5% by weight of a chitosan having a degree of acetylation less than 20% and a weight average molecular mass of between 100,000 and 1,500,000 g/mol, said solution having a pH greater than or equal to 6.2, and advantageously between 6.2 and 7.2, said solution not containing chitosan having a degree of acetylation greater than 20%, said solution being liquid and homogeneous at ambient temperature. The invention also relates to an aqueous solution as previously described, characterised in that it is preparable by a method comprising at least the following steps: - dissolving the chitosan in water by adding acid such as a weak acid, said weak acid being advantageously chosen from the group consisting of acetic acid, glycolic acid, lactic acid, glutamic acid, and the mixtures of same, and - readjusting the pH by dialysis, preferably at ambient temperature, in order to obtain an aqueous solution having a pH greater than or equal to 6.2, advantageously between 6.2 and 7.2, and preferably between 6.25 and 7.1.
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机译:本发明涉及在生理上可接受的介质中含有0.1至4.5重量%的乙酰化度小于20%且重均分子量为100,000至1,500,000的壳聚糖的可注射壳聚糖的均质水溶液。 g / mol,所述溶液具有大于或等于6.2的pH,并且有利地在6.2至7.2之间,所述溶液不含乙酰化度大于20%的壳聚糖,所述溶液在环境温度下为液体且均匀。本发明还涉及如前所述的水溶液,其特征在于其可以通过至少包括以下步骤的方法制备:-通过加入酸例如弱酸将壳聚糖溶解在水中,所述弱酸有利地选自由乙酸,乙醇酸,乳酸,谷氨酸及其混合物组成的组,以及-最好在环境温度下通过透析重新调节pH值,以获得pH大于或等于pH的水溶液6.2,有利地在6.2和7.2之间,并且优选地在6.25和7.1之间。
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