A composition comprising an oncolytic poxvirus comprising a deficient gene encoding the large subunit of ribonucleotide reductase (I4L) and / or the small subunit of ribonucleotide reductase (F4L) and a deficient gene encoding thymidine kinase (J2R) and further comprising a suicide gene for use in treating cancer in combination with one or more substances effective in anticancer therapy, wherein the one or more substances effective in anticancer therapy are selected from irinotecan and oxaliplatin.
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