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SYSTEM AND METHOD FOR MODULATING STRESS GRANULE ASSEMBLY

机译:应力颗粒装配的系统和方法

摘要

A system and method for modulating stress granule assembly, utilizing a protein construct that has a cell penetrating protein fused to one or more proteins that can bind with an NTF2- like domain of a G3BP protein. By configuring the protein construct with an appropriate number of proteins that being with NTF2-like domains, stress granule assembly can be upregulated or downregulated as needed to treat patients.
机译:一种利用蛋白质构建体调节应力颗粒组装的系统和方法,该蛋白质构建体具有与一种或多种蛋白质融合的细胞穿透蛋白质,该蛋白质可以与G3BP蛋白质的NTF2样结构域结合。通过用适当数量的具有NTF2样结构域的蛋白质来配置蛋白质构建体,可以根据治疗患者的需要上调或下调应激颗粒的装配。

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