COMBINATION FOR USE IN THE TREATMENT OF EXTRA-OESOPHAGEAL SYMPTOMS OF GASTRIC REFLUX

摘要

The present invention regards a combination (C) comprising: (I) a composition (C1) comprising a mixture (M1) comprising, or alternatively, consisting of (i-a) an alginic acid, or a salt thereof, and i-b) a hyaluronic acid, or a salt thereof; and (II) a composition (C2) comprising a mixture (M2) comprising, or alternatively, consisting of: (iii-a) an alginic acid, or a salt thereof, (iii-b) a bicarbonate and/or carbonate salt and (iii-c) a simethicone and/or dimethicone; said combination (C) being for use in a method for the preventive and/or curative treatment of diseases, symptoms or disorders deriving from extraoesophageal reflux or laryngopharyngeal reflux (LPR) or from the backflow of the gastric content or acid gastric vapours from the stomach in at least one extraoesophageal area. Preferably, said combination (C) is for use in a method for the treatment of the lacrimal dysfunction syndrome (LDS) or dry eye syndrome, or of symptoms or disorders deriving therefrom, in subjects with Reflux Symptom Index (RSI) greater than 13 and Ocular Surface Disease Index (OSDI) greater than 12.