PHARMACEUTICAL COMPOSITION COMPRISING OF REMOGLIFLOZIN OR SALT OR ESTER THEREOF AND VILDAGLIPTIN OR SALT THEREOF

摘要

The invention relates to a stable pharmaceutical composition comprising remogliflozin or salt or ester thereof, and vildagliptin or salt thereof. In particular disclosed is a pharmaceutical composition comprising a first portion and a second portion, wherein said first portion comprises granules of remogliflozin or salt or ester thereof and a pharmaceutically acceptable excipient, said second portion comprises granules of vildagliptin or salt thereof and a pharmaceutically acceptable excipient; wherein granules of remogliflozin or salt or ester thereof are preapred by wet granulation and granules of vildagliptin or salt thereof are prepared by roller compaction; wherein said portions are compressed together to obtain a bilayer tablet dosage form which is coated with non-aquous seal coat.