A CLASS OF SMALL-MOLECULE COMPOUNDS AND THEIR PRODRUGS FOR INTERVENTION WITH CAMK2A, AND THEIR USE IN ACUTE BRAIN INJURIES AND CENTRAL HYPERSOMNIAS

摘要

The present invention relates to novel compounds of formula I, wherein X is C or N, R₁ and R₂ are selected from H, halogen, -OH, -NH₂, -N0₂, -C₁-C₆-alkyl, -O-CrCe-alkyl, -O- benzyl (-O-Bn), and R₃ is selected from -OH, -NH₂, -O-C₁-C₆-alkyl, -CrCe-alkyl-O- C(=0)-C₁-C₆-alkyl, -O-aryl, -O-substituted aryl, -NH-C₁-C₆-alkyl, -NH-aryl, -NH-substituted aryl. The invention further relates to compounds of formula (I) for use as a medicament for treating brain injuries, central hypersomnia or in cataplexy.