APPLICATION OF QUERCETIN IN PREPARATION OF DRUG FOR PREVENTION AND TREATMENT OF DRUG-INDUCED LIVER INJURY

摘要

The present invention relates to a medical use of quercetin in prevention and treatment of drug-induced acute liver injury, and in particular, to application of the quercetin in preparation of a drug for prevention and treatment of liver injury caused by acetaminophen. Animal experiments prove that the quercetin controls abnormal rise in biochemical indicators related to acetaminophen-induced liver functions and changes in pathological structures, and increases the content of in-vivo antidote GSH in acetaminophen-induced liver tissue injury; the quercetin is an oral preparation or injection preparation, the administration dosage may be changed according to the age, the weight, the intake amount of acetaminophen, the arrangement of a treatment course and the like of a patient, a recommended administration dosage for a person is 40 mg/kg/d, and an oral administration mode is recommended; the quercetin can effectively resist liver injury caused by acetaminophen, and can be used for preparing a drug for treating liver injury caused by acetaminophen.