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HIGH-THROUGHPUT METHODS TO CHARACTERIZE PHAGE RECEPTORS AND RATIONAL FORMULATION OF PHAGE COCKTAILS
HIGH-THROUGHPUT METHODS TO CHARACTERIZE PHAGE RECEPTORS AND RATIONAL FORMULATION OF PHAGE COCKTAILS
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机译:表征噬菌体受体的高通量方法和噬菌体鸡尾酒的合理配方
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摘要
The present invention provides for a method for screening for gene function for a bacteriophage, the method comprising: (1) (a) providing one or more host organism, such as a species or strain, libraries, (b) providing randomly barcoded transposon sequencing (such as RB-TnSeq), and (c) screening for loss-of-function (LOF) mutant phenotypes; or (2) (a) providing one or more DNA barcoded overexpression strain libraries (such as Dub-seq) using DNA of the host organism and/or phage, and (b) screening for gain-of-function (GOF).
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