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Full siblings analysis using Genotyping

机译:使用基因分型进行完整的兄弟姐妹分析

摘要

Provided is a blood relationship analysis method using genotyping, which comprises: step (A) of analyzing, based on a marker, a genotype of entities whose likelihood is to be checked; step (B) of inputting a genotyping result data as a result of the step (A); step (C) of inputting an allele frequency from the genotyping result data of the step (B); step (D) of comparing whether an allelotype is matched between the entities whose likelihood is to be checked, setting an identity by descent (IBD) formula in accordance with the number of cases with which the allelotype is matched, and applying an IBD constant in accordance with the number of cases of the likelihood to the set IBD formula, and thus extracting a likelihood ratio; and step (E) of confirming a probability result of the highest value of the step (D) to determine the likelihood. According to the present invention, an analysis process is simplified such that analysis can be performed in a short time, thereby increasing correctness, efficiency, simplicity and specialty in business, and providing a correct result in family line confirmation, selection breeding and discharge effect examination (sibling analysis for a discharged seed).
机译:提供一种利用基因分型的血液关系分析方法,其包括:步骤(A),基于标志物,分析其可能性待检查的实体的基因型;以及,步骤(B),作为步骤(A)的结果,输入基因分型结果数据;步骤(C),从步骤(B)的基因分型结果数据输入等位基因频率;步骤(D),比较是否要检查其可能性的实体之间是否存在等位基因型匹配,根据等位基因型匹配的情况数,通过血统(IBD)公式设置同一性,并在其中应用IBD常数根据所设置的IBD公式的似然性的数目,从而提取似然比;步骤(E),确认步骤(D)的最大值的概率结果以确定似然性。根据本发明,简化了分析过程,使得可以在短时间内进行分析,从而提高了正确性,效率,简便性和业务专业性,并为家系确认,选择育种和出院效果检查提供了正确的结果。 (对排出的种子进行同级分析)。

著录项

  • 公开/公告号KR20190139480A

    专利类型

  • 公开/公告日2019-12-18

    原文格式PDF

  • 申请/专利权人 BLUGEN KOREA;

    申请/专利号KR20180066025

  • 发明设计人 JISUNG HAN;WOO JAI LEE;

    申请日2018-06-08

  • 分类号G16B30;C12Q1/68;

  • 国家 KR

  • 入库时间 2022-08-21 11:08:38

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