ONCOLYTIC VIRUS GUIDING IMMUNE CELL OR ANTIBODY THERAPEUTICS THE IMMUNE CELLS SPECIFIC FOR THE ANTIGEN INDUCED BY THE VIRUS AND COMBINATION THERAPY USING THEREOF

摘要

The present invention relates to an oncolytic virus that induces an immune cell or an antibody therapeutic agent, and more particularly, an oncolytic virus comprising an expression cassette of an antigen labeled on the cell surface and specifically recognized by an immune cell or an antibody therapeutic agent, and Combination treatment composition for cancer containing the virus; And an antigen-specific immune cell introduced by an oncolytic virus and a combination treatment composition for cancer comprising the immune cell. The combination treatment method for cancer comprising administering an oncolytic virus according to the present invention and administering an immune cell or an antibody therapeutic agent that specifically recognizes the antigen after the administration is performed by allowing the immune cells to be induced into cancer cells. In the treatment of cancer, particularly solid cancer, a combination treatment method for cancer that can overcome the limitations of each of the existing immune cell and oncolytic virus therapy is provided.