A micropillar array is provided for assaying the differentiation, encapsulation, and / or packaging of micropillars by oligodendrocytes into oligodendrocytes. Methods of using micropillar arrays for screening of candidate agents that enhance the differentiation, encapsulation, and / or packaging of micropillars by oligodendrocytes into oligodendrocytes are also described herein. Is provided. Systems comprising micropillar arrays and oligodendrocyte precursor cells are also provided.
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