METHOD FOR PREDICTION OF THE RISK OF DEVELOPING WEB-ASSOCIATED TUMORS IN THE PATIENTS WITH ACUTE EBV-INFECTION

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to laboratory diagnostics, and can be used for prediction of developmental risk EBV-associated tumors in patients with acute EBV-infection. That is ensured by detecting peripheral blood leukocytes expressing transcription variants of mRNA receptors and components of TGFB1-associated signalling pathways: TGFB1, TGFBR1, TGFBR2, Smad2, Smad3, Smad4, PRKCB, MAP3K7, MAP3K11, MAP3K1, MAPK1, MAP2K4, MAPK8, JUN, TRAF6, IKBKG, IKBKB, CHUK, ELP1, NFKBI-α, NFKBI-β, NFKB1, RELA using a microchip with oligonucleotide probes applied on it, complementary to sequences of said mRNA. Increase of expression levels of mRNA of transcription version 1 of Smad2, transcription version 4 of IKBKG, transcription version 1 of IKBKG and total level of mRNA of NFKBI, and reduction of expression level of mRNA of transcription version 2 of PRKCB are considered as a risk factor of development EBV-associated tumors.;EFFECT: invention enables to predict EBV-associated tumors at early stage of tumor transformation progression.;1 cl, 3 dwg, 1 tbl, 4 ex