MONOCLONAL ANTIBODIES WHICH SPECIFICALLY BIND TO THE BETA-CHAIN REGION OF THE TRBV-9 FAMILY OF THE HUMAN T-CELL RECEPTOR, AND METHODS FOR USE THEREOF

摘要

FIELD: immunology.;SUBSTANCE: present invention relates to immunology. Disclosed are an antibody and its antigen-binding fragment capable of specific binding to a segment of the beta chain of the TRBV9 family of the human T-cell receptor. Also disclosed are nucleic acids, expression vectors, a method for producing a host cell, a host cell, a method for producing an antibody or an antigen-binding fragment thereof and pharmaceutical compositions. What is also described is a method for inhibiting the biological activity of the T-cell receptor, a method of treating a disease or disorder mediated by a human T-cell receptor, and using the antibody or pharmaceutical composition.;EFFECT: present invention can find further application in therapy of various conditions, particularly celiac disease, T-cell leukemia and T-cell lymphoma.;20 cl, 3 dwg, 4 tbl, 8 ex