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ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION AND DRUG PREPARATION FOR HIV AND AIDS THERAPY

机译:艾滋病毒/艾滋病治疗的有效成分,药物成分和药物制备

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to micronized monoclinic symmetry crystals (MMSC) with average particle diameter of ≤130 mcm sodium {[4-({[4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetyl}amino)-3-chlorophenyl]-sulphonyl}(propanoyl)azanide - of formula Ib, sodium {[4-({[4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetyl}amino)-3-chlorophenyl]-sulphonyl}(propanoyl)azanide of formula Ib. Crystals are an active component of a pharmaceutical composition and a medicinal agent for use in therapy of human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS). Micronized crystals of the compound of formula Ib; ;have the following crystal characteristics:; <TableGroup colSep="1" cols="2" rowSep="1"> <Colspec colName="c1" colWidth="42mm"/> <Colspec colName="c2" colWidth="43mm"/> <Tbody> <Row> <entry colSep="1" rowSep="1">crystalline form</entry> <entry colSep="0" rowSep="1">monoclinic</entry> </Row> <Row> <entry colSep="1" rowSep="1">Z</entry> <entry colSep="0" rowSep="1">1h</entry> </Row> <Row> <entry colSep="1" rowSep="1">spatial group</entry> <entry colSep="0" rowSep="1">P21/c</entry> </Row> <Row> <entry colSep="1" rowSep="1">a</entry> <entry colSep="0" rowSep="1">15.0367(4)Å</entry> </Row> <Row> <entry colSep="1" rowSep="1">b</entry> <entry colSep="0" rowSep="1">25.2592(6)Å</entry> </Row> <Row> <entry colSep="1" rowSep="1">c</entry> <entry colSep="0" rowSep="1">6.89727(19)Å</entry> </Row> <Row> <entry colSep="1" rowSep="1">α</entry> <entry colSep="0" rowSep="1">-</entry> </Row> <Row> <entry colSep="1" rowSep="1">β</entry> <entry colSep="0" rowSep="1">91.216(2)°</entry> </Row> <Row> <entry colSep="1" rowSep="1">γ</entry> <entry colSep="0" rowSep="1"/> </Row> <Row> <entry colSep="1" rowSep="0">V, Ά</entry> <entry>2623.79(12)Å<Sup>3</Sup></entry> </Row> </Tbody> </TableGroup> </TableFormula> </Table> ;and indicators powder X having interplanar spacings (D) and relative intensities (I<Sub>rel</Sub> = I/I<Sub>o</Sub> × 100) diffraction peaks of the monoclinic phase of the sample in angle region 2θ° 6°–30°:; <Table> <TableFormula> <Title/> <TableGroup colSep="1" cols="2" rowSep="1"> <Colspec colName="c1" colWidth="17mm"/> <Colspec colName="c2" colWidth="28mm"/> <Tbody> <Row> <entry colSep="1" rowSep="1">(D)</entry> <entry>I/I<Sub>o</Sub>×100</entry> </Row> <Row> <entry colSep="1" rowSep="1">7.6</entry> <entry colSep="0" rowSep="1">29</entry> </Row> <Row> <entry colSep="1" rowSep="1">7.2</entry> <entry colSep="0" rowSep="1">100</entry> </Row> <Row> <entry colSep="1" rowSep="1">6.5</entry> <entry colSep="0" rowSep="1">37</entry> </Row> <Row> <entry colSep="1" rowSep="1">4.7</entry> <entry colSep="0" rowSep="1">67</entry> </Row> <Row> <entry colSep="1" rowSep="1">4.1</entry> <entry colSep="0" rowSep="1">70</entry> </Row> <Row> <entry colSep="1" rowSep="0">3.9</entry> <entry colSep="0" rowSep="0">85</entry> </Row> </Tbody> </TableGroup> </TableFormula> </Table> ;MMSC with said monoclinic crystal structure have DSC values within 244–253.5 °C with peak of 250 °C. Average particle diameter is from 10 to 130 mcm. Pharmaceutical composition has a solid form and additionally contains as excipients at least lactose monohydrate, sodium croscarmellose, povidone and magnesium stearate. Medicinal preparation is used in the form of an oral form.;EFFECT: comparative data on use of micronized and non-micronized particles (Ib and Ia, respectively) show that micronized particles increase exposure time of compound Ib in blood plasma.;17 cl, 4 dwg, 2 tbl, 8 ex </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译:</span>发明领域:本发明涉及平均粒径≤130mcm的钠{[4-({[4-溴-3-(3-氯-5-氰基苯氧基)-2式Ib的-[氟苯基]乙酰基}氨基}氨基)-3-氯苯基]-磺酰基}(丙酰基)氮杂叠氮钠{[4-({[4-溴-3-(3-氯-5-氰基苯氧基)-2-式Ib的氟苯基]乙酰基}氨基} -3-氯苯基]-磺酰基}(丙酰基)叠氮化物。晶体是药物组合物的活性成分和用于治疗人类免疫缺陷病毒(HIV)和获得性免疫缺陷综合症(AIDS)的药物。式Ib化合物的微粉化晶体; <Image file =“ 00000017.JPG” he =“ 59” imgContent =“ undefined” imgFormat =“ JPEG” wi =“ 135” /> 具有以下晶体特征: <表格> <TableFormula> <标题/> <TableGroup colSep =“ 1” cols =“ 2” rowSep =“ 1”> <Colspec colName =“ c1” colWidth =“ 42mm” /> <Colspec colName =“ c2” colWidth =“ 43mm” /> <身体> <行> <entry colSep =“ 1” rowSep =“ 1”>晶形</ entry> <entry colSep =“ 0” rowSep =“ 1”>单斜</ entry> </ Row> <行> <entry colSep =“ 1” rowSep =“ 1”> Z </ entry> <entry colSep =“ 0” rowSep =“ 1”> 1小时</ entry> </ Row> <行> <entry colSep =“ 1” rowSep =“ 1”>空间组</ entry> <entry colSep =“ 0” rowSep =“ 1”> P21 / c </ entry> </ Row> <行> <entry colSep =“ 1” rowSep =“ 1”> a </ entry> <entry colSep =“ 0” rowSep =“ 1”> 15.0367(4)Å</ entry> </ Row> <行> <entry colSep =“ 1” rowSep =“ 1”> b </ entry> <entry colSep =“ 0” rowSep =“ 1”> 25.2592(6)Å</ entry> </ Row> <行> <entry colSep =“ 1” rowSep =“ 1”> c </ entry> <entry colSep =“ 0” rowSep =“ 1”> 6.89727(19)Å</ entry> </ Row> <行> <entry colSep =“ 1” rowSep =“ 1”>α</ entry> <entry colSep =“ 0” rowSep =“ 1”>-</ entry> </ Row> <行> <entry colSep =“ 1” rowSep =“ 1”>β</ entry> <entry colSep =“ 0” rowSep =“ 1”> 91.216(2)°</ entry> </ Row> <行> <entry colSep =“ 1” rowSep =“ 1”>γ</ entry> <entry colSep =“ 0” rowSep =“ 1” /> </ Row> <行> <entry colSep =“ 1” rowSep =“ 0”> V,Ά</ entry> <entry> 2623.79(12)Å<Sup> 3 </ Sup> </ entry> </ Row> </ Tbody> </ TableGroup> </ TableFormula> </ Table> ;和指示剂X,其样品的单斜晶相具有晶面间距(D)和相对强度(I <Sub> rel </ Sub> = I / I <Sub> o </ Sub>×100)的衍射峰2θ°6°–30°区域:; <表格> <TableFormula> <标题/> <TableGroup colSep =“ 1” cols =“ 2” rowSep =“ 1”> <Colspec colName =“ c1” colWidth =“ 17mm” /> <Colspec colName =“ c2” colWidth =“ 28mm” /> <身体> <行> <entry colSep =“ 1” rowSep =“ 1”>(D)</ entry> <entry> I / I <Sub> o </ Sub>×100 </ entry> </ Row> <行> <entry colSep =“ 1” rowSep =“ 1”> 7.6 </ entry> <entry colSep =“ 0” rowSep =“ 1”> 29 </ entry> </ Row> <行> <entry colSep =“ 1” rowSep =“ 1”> 7.2 </ entry> <entry colSep =“ 0” rowSep =“ 1”> 100 </ entry> </ Row> <行> <entry colSep =“ 1” rowSep =“ 1”> 6.5 </ entry> <entry colSep =“ 0” rowSep =“ 1”> 37 </ entry> </ Row> <行> <entry colSep =“ 1” rowSep =“ 1”> 4.7 </ entry> <entry colSep =“ 0” rowSep =“ 1”> 67 </ entry> </ Row> <行> <entry colSep =“ 1” rowSep =“ 1”> 4.1 </ entry> <entry colSep =“ 0” rowSep =“ 1”> 70 </ entry> </ Row> <行> <entry colSep =“ 1” rowSep =“ 0”> 3.9 </ entry> <entry colSep =“ 0” rowSep =“ 0”> 85 </ entry> </ Row> </ Tbody> </ TableGroup> </ TableFormula> </ Table> ;具有上述单斜晶体结构的MMSC的DSC值在244–253.5°C之间,峰值为250°C。平均粒径为10至130mcm。药物组合物具有固体形式,并且另外包含至少一水合乳糖,交联羧甲基纤维素钠,聚维酮和硬脂酸镁作为赋形剂。药物制剂以口服形式使用;效果:关于使用微粒化和非微粒化颗粒(Ib和Ia)的比较数据)分别表明,微粒化会增加化合物Ib在血浆中的暴露时间。; 17 cl,4 dwg,2 tbl,8 ex </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33">著录项</h2> <div class="getdents"> <ul> <li> <p><span>公开/公告号</span><span>RU2716257C1</span></p> <p><span>专利类型</span><span></span></p> </li> <li> <p><span>公开/公告日</span><span>2020-03-11</span></p> <p><span>原文格式</span><span>PDF</span></p> </li> <li> <div class="apply"> <p><span style="width: 90px;display: inline-block;">申请/专利权人</span><span id="patentee" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=12_13&sertext=IVASHCHENKO ANDREJ ALEKSANDROVICH&option=232">IVASHCHENKO ANDREJ ALEKSANDROVICH;</a> </span></p> <span class="designer hoverxs" style="display: none;">展开▼</span> </div> <p><span>申请/专利号</span><span style="width: 250px;">RU2019113338</span></p> </li> <li> <div class="apply"> <p><span style="width: 90px;display: inline-block;">发明设计人</span><span id="patentee" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=12_13&sertext=IVASHCHENKO ALEKSANDR VASILEVICH (US)&option=202">IVASHCHENKO ALEKSANDR VASILEVICH (US);</a><a href="/search.html?doctypes=12_13&sertext=IVASHCHENKO ANDREJ ALEKSANDROVICH (RU)&option=202">IVASHCHENKO ANDREJ ALEKSANDROVICH (RU);</a><a href="/search.html?doctypes=12_13&sertext=SAVCHUK NIKOLAJ FILIPPOVICH (US)&option=202">SAVCHUK NIKOLAJ FILIPPOVICH (US);</a><a href="/search.html?doctypes=12_13&sertext=IVASHCHENKO ALENA ALEKSANDROVNA (US)&option=202">IVASHCHENKO ALENA ALEKSANDROVNA (US);</a> </span></p> <span class="designer hoverxs" style="display: none;">展开▼</span> </div> <p><span>申请日</span><span>2019-04-30</span></p> </li> <li> <p style="width: 100%;"><span>分类号</span><span style="width: 80%;">C07C311/51;A61K31/18;A61P31/18;</span> </p> </li> <li> <p style="width: 100%;"><span>国家 </span><span style="width: 93%;">RU</span></p> </li> <li><p style="width: 100%;"> <span >入库时间</span> <span>2022-08-21 11:02:36</span></p> </li> </ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity"> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul > <li >专利</li> <li >外文文献</li> <li >中文文献</li> </ul> </div> <div class="similarity_details"> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061203805841.html">治疗艾滋病毒感染后致神经炎症介导神经元损伤的药物</a> <b>[P]</b> . <span> 中国专利: CN108125939B </span> <span> . 2020.06.26</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120103609908.html">聚醚类抗生素K-41B、K-41A在制备治疗或预防艾滋病毒药物中的应用</a> 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Yu,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Li Hi-yan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Li Hi-yan,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Yang Yun-fei&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yang Yun-fei </a> <a href="/conference-foreign-194088/" target="_blank" rel="nofollow" class="tuijian_authcolor">Asian Particle Technology Symposium .</a> <span>2007</span> </span> </div> </li> <li> <div> <b>9. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061217680.html">Queer bricolage: A visual study of metaphors in HIV/AIDS pharmaceutical drug advertising.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Kang, Helen Hyunji.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kang, Helen Hyunji. </a> <span>2005</span> </span> </div> </li> <li> <div> <b>10. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040005887811.html">The Impact of the AIDS Drug Assistance Program (ADAP) on Use of Highly Active Antiretroviral and Antihypertensive Therapy among HIV-Infected Women</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Thomas Yi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Thomas Yi,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Jennifer Cocohoba&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jennifer Cocohoba,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Mardge Cohen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Mardge Cohen,</a> <span>-1</span> </span> </div> </li> <li> <div> <b>11. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000126007958.html">Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). Our experience from a 2-year prospective study in Constanta County, Romania420Epicardial adipose tissue as a predictor of cardiovascular outcome in patients with ACS undergoing PCI?Arterial and pulmonary hypertension423Dependence between heart rhythm disorers and ID polymorphism of ACE gene in hypertensive patients424Molecular mechanisms underlying the beneficial effects of Urocortin 2 in pulmonary arterial hypertension425Inhibition of TGf-b axis and action of renin-angiotensin system in human ascending aorta aneurysms426Early signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy: a new, non invasive biomarker432Can circulating microRNAs distinguish type 1 and type 2 myocardial infarction?433Design of a high-throughput multiplex proteomics assay to identify left ventricular diastolic dysfunction in diabetes434Monocyte-derived and P-selectin-carrying microparticles are differently modified by a low fat diet in patients with cardiovascular risk factors who will and who will not develop a cardiovascular event435Red blood cell distribution width assessment by polychromatic interference microscopy of thin films in chronic heart failure436Invasive and noninvasive evaluation of quality of radiofrequency-induced cardiac denervation in patients with atrial fibrillation437The effect of therapeutic hypothermia on the level of brain derived neurotrophic factor (BDNF) in sera following cardiopulmonary resustitation438Novel biomarkers to predict outcome in patients with heart failure and severe aortic stenosis439Biological factors linking depression and anxiety to cardiovascular disease440Troponins and myoglobin dynamic at coronary arteries graftingInvasive, non-invasive and molecular imaging443Diet composition effects on the genetic typing of the mouse ob mutation: a micro-ultrasound characterization of cardiac function, macro and micro circulation and liver steatosis444Characterization of pig coronary and rabbit aortic lesions using IV-OCT quantitative analysis: correlations with histologyGene therapy and cell therapy447Enhancing the survival and angiogenic potential of mouse atrial mesenchymal cells448VCAM-1 expression in experimental myocardial infarction and its relation to bone marrow-derived mononuclear cell retentionTissue engineering451Advanced multi layered scaffold that increases the maturity of stem cell-derived human cardiomyocytes452Response of engineered heart tissue to simulated ischemia/reperfusion in the presence of acute hyperglycemic conditions453Serum albumin hydrogels prevent de-differentiation of neonatal cardiomyocytes454A novel paintbrush technique for transfer of low viscosity ultraviolet light curable cyan methacrylate on saline immersed in-vitro sheep heart</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=V Garcia-Martinez&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">V Garcia-Martinez,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=C Lopez Sanchez&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">C Lopez Sanchez,</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=W Hamed&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">W Hamed,</a> <span>2016</span> </span> </div> </li> <li> <div> <b>12. </b><a class="enjiyixqcontent" href="/ntis-science-report_pb_thesis/02071741191.html">HIV/AIDS Drugs: Funding Implications of New Combination Therapies for Federal and211 State Programs</a> <b>[R] </b> . <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> </a> <span>1998</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201292541861.html">Immunological responses of HIV/AIDS patients treated with Nevirapine versus Efavirenz based highly active anti-retroviral therapy in Addis Ababa, Ethiopia: A retrospective cohort study</a> <b>[J]</b> <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Zemedu Mehamed Tirfe&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Zemedu Mehamed Tirfe</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Tekabe Abdosh Ahmed&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Tekabe Abdosh Ahmed</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=Negga Baraki Tedla&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Negga Baraki Tedla</a> <span> <a href="/journal-cn-56166/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 健康(英文) </a> </span> <span> . 2013</span><span>,第9期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-12163_thesis/02022573989.html">植物中抗艾滋病毒有效成分研究进展</a> <b>[C]</b> <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=张鸿雁&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张鸿雁</a> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=张兰珍&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张兰珍</a> <span> <a href="/conference-cn-12163/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中华中医药学会中药化学分会第五届学术年会 </a> <span> <span> . 2010</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020314119370.html">五味子科药用植物的抗艾滋病毒活性成分和ISSR分子标记</a> <b>[A] </b> <span> <a href="/search.html?doctypes=1_2_3_4_5_6_7_1-0_9_4-0&sertext=陈敏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈敏</a> <span> . 2004</span> </span> </div> </li> </ul> </div> </div> <!--- <div class="correlation "> <h3 class="all_title" id="enpatent77">相关文献</h3> <div class="correlationtab clearfix"> <ul> <li class="active">中文文献</li> <li>外文文献</li> <li>专利</li> </ul> </div> <div class="correlation_details"> <ul> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704016504275.html">从人学视角透视中国特色社会主义制度建设</a> <b>[J]</b> . <span> <a 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Information and Communication Management .</a> <span>2009</span><span>,第1卷</span><span>,第3期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译: </span>分布式校园信息网络中的安全环境-香川大学信息网络的现状和安全措施的报告 </p> </li> </ul> <ul> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704016504275.html">专利专利分散型キャンパス情報ネットワークにおけるセキュリティ環境-香川大学情報ネットワークにおけるセキュリティ対策の現状と報告</a> <b>[J]</b> . <span> <a href="">河内一芳,</a> <a href="">曽根計俊,</a> <a href="">川口政秀,</a> <a href="/journal-foreign-37017/" target="_blank" rel="nofollow" class="tuijian_authcolor">電子情報通信学会技術研究報告. 情報通信マネジメント. Information and Communication Management .</a> <span>2009</span><span>,第60期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译:</span>分布式校园信息网络中的安全环境-香川大学信息网络的现状和安全措施的报告 </p> </li> </ul> </div> </div>--> </div> </div> </div> </div> <div class="right "> </div> </div> <div id="thesis_down_palent" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="xz('06130400511671','13',6,1,this,'9999',0)" title="专利原文即时下载到本机" prompt="0101301">获取专利</div> <span id="06130400511671down" data-source="6," data-out-id="RU2716036C1," data-f-source-id="6" data-title="ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION AND DRUG PREPARATION FOR HIV AND AIDS THERAPY" data-price="20" data-transnum="0" style="display:none;"></span> <div class="right_btn"> <ul> <li class="gouwuche"> <!-- <a href="javascript:void(0);" onclick="link_analysis('/shoppingcart/auth/list.html',this)">购物车</a>--> </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)" title="意见反馈">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);" title="回到顶部">回到顶部</a> </li> <li class="shouye"> <a href="/" title="首页">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html" title="关于掌桥">关于掌桥</a></li> <li><a href="/help/helpmap.html" title="资源导航">资源导航</a></li> <li><a href="/help/helpguide.html" title="新手指南">新手指南</a></li> <li><a href="/help/helpcenter.html" title="常见问题">常见问题</a></li> <li><a href="/sitemap.html" title="网站地图">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9" title="版权声明">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱:kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备:11010802029741号 </span> <span>ICP备案号:<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank" title="ICP备案号">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.8.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.8.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.8.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.8.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.8.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.8.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.8.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.8.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/newmail.js?v=5.8.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.8.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.8.7"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.8.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/sse.js?v=5.8.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js?v=5.8.7"></script> </body> </html>