CELLULES EXPRIMANT UN RÉCEPTEUR ANTIGÉNIQUE CHIMÉRIQUE OU UN TCR MANIPULÉ ET COMPRENANT UNE SÉQUENCE DE NUCLÉOTIDES EXPRIMÉE DE MANIÈRE SÉLECTIVE

摘要

The present invention provides a cell which expresses a chimeric antigen receptor (CAR) or an engineered T-cell receptor (TCR), the cell comprising a nucleotide sequence of interest (NOI) which is selectively expressed by the cell depending on: i) the differentiation/exhaustion state of the cell; or ii) the presence of an environmental metabolite in the microenvironment of the cell.