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一种抑制p38激酶活性的多肽及其应用

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摘要

本发明公开了一种抑制p38激酶活性的多肽及其应用。该多肽，是下述氨基酸残基序列之一：1)序列表中的SEQ ID NO：1；2)序列表中的SEQ ID NO：3。本发明的多肽可以进入细胞，并在体内体外特异地抑制p38激酶活性，阻断p38通路的信号传递，可以抑制炎症反应。

著录项

公开/公告号CN100513419C

专利类型发明授权
公开/公告日2009-07-15

原文格式PDF
申请/专利权人北京大学;
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申请/专利号CN200610089136.X
发明设计人顾军;傅璟;
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申请日2006-08-04
分类号
代理机构北京纪凯知识产权代理有限公司;
代理人关畅
地址 100871 北京市海淀区颐和园路5号北京大学
入库时间 2022-08-23 09:02:34

法律信息

法律状态公告日

法律状态信息

法律状态
2009-07-15

授权

授权
2007-04-11

实质审查的生效

实质审查的生效
2007-02-14

公开

公开

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3. isolated polynucleotide, expression cassette, host cell, isolated polypeptide, non-human transgenic animal that has been altered to express an alkali resistant mutant polypeptide, an antibody that specifically binds to an alkali resistant mutant polypeptide, a mutation detection kit alk inhibitor resistance in a biological sample, and methods for evaluating a biological sample for an alk inhibitor resistance mutation to diagnose cancer that is resistant to or likely to develop resistance to at least one alkaline inhibitor. small alk molecule kinase, to evaluate a biological sample for an alk inhibitor resistance mutation, to diagnose cancer that is resistant to or likely to develop resistance to pf-02341066 in a patient, to specifically reduce expression of an alk-resistant mutant to treat cancer associated with activating aberrant loop capacity that is resistant to at least one small molecule alk kinase inhibitor treating an aberrant cancer that is resistant to pf-02341066, identifyin [P] . BR112012026239A2 . 2018-06-26

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4. Polinucleotu00eddeo insulated tape of expression, host cell, isolated transgenic non-human animal polypeptide, which has been modified to express a polypeptide mutant with resistance to ALK, antibody that binds specifically to a polypeptide mutant with resistance to ALK, kit p For detection of a mutation with resistance to ALK inhibitor in a biological sample, and,Methods for evaluating a biological sample as a mutation with resistance to ALK inhibitor, for diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to evaluate a biological sample that Anto a mutation with resistance to ALK inhibitor.For diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to assess the biological sample as a mutation with resistance to ALK inhibitor, a cancer that is resistant to dianosticar Or is likely to develop resistance to PF - 02341066 in a pati [P] . BR112012026239A2 . 2016-11-29

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5. p38 MAP NOVEL COMPOUNDS HAVING ANTI-INFLAMMATORY ACTIVITY AS P38 MAP KINASE INHIBITOR [P] . KR102298450B1 . 2021-09-08

机译： P38地图具有抗炎活性的地图新化合物，如P38映射激酶抑制剂