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一种靶向人结肠癌细胞的特异性多肽

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摘要

本发明属于生物医学领域，具体涉及一种对结肠癌细胞有靶向作用的多肽及其用途。该多肽为以下任意：（1）多肽的氨基酸序列为：YPEIWPTDHKLM（SEQ ID No.1）；（2）在（1）所述的多肽分子中经过缺失、插入或置换一个或几个氨基酸且与（1）所述的多肽分子具有相同生物学功能的多肽衍生物。所述的多肽能够与结肠癌细胞特异性结合，而与正常的肠上皮细胞无特异性作用，而且作用效果明显，为临床治疗提供了可靠的科学依据。

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公开/公告号CN108610396B

专利类型发明专利
公开/公告日2021-04-09

原文格式PDF
申请/专利权人中国医科大学;
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申请/专利号CN201810386080.7
发明设计人赵琳;魏敏杰;于丽凤;贾真;卫倩;
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申请日2018-04-26
分类号C07K7/08(20060101);G01N33/574(20060101);G01N33/68(20060101);A61K47/42(20170101);A61P35/00(20060101);
代理机构21107 沈阳亚泰专利商标代理有限公司;
代理人陈铮
地址 110122 辽宁省沈阳市沈北新区蒲河路77号
入库时间 2022-08-23 11:38:40

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1. 一种靶向人结肠癌细胞的特异性多肽 [P] . 中国专利： CN108610396B . 2021.04.09
2. 一种与人结肠癌细胞特异性结合的多肽 [P] . 中国专利： CN108640976B . 2021.04.09
3. isolated polynucleotide, expression cassette, host cell, isolated polypeptide, non-human transgenic animal that has been altered to express an alkali resistant mutant polypeptide, an antibody that specifically binds to an alkali resistant mutant polypeptide, a mutation detection kit alk inhibitor resistance in a biological sample, and methods for evaluating a biological sample for an alk inhibitor resistance mutation to diagnose cancer that is resistant to or likely to develop resistance to at least one alkaline inhibitor. small alk molecule kinase, to evaluate a biological sample for an alk inhibitor resistance mutation, to diagnose cancer that is resistant to or likely to develop resistance to pf-02341066 in a patient, to specifically reduce expression of an alk-resistant mutant to treat cancer associated with activating aberrant loop capacity that is resistant to at least one small molecule alk kinase inhibitor treating an aberrant cancer that is resistant to pf-02341066, identifyin [P] . BR112012026239A2 . 2018-06-26

机译：分离的多核苷酸，表达盒，宿主细胞，分离的多肽，已被改变以表达耐碱突变体多肽的非人类转基因动物，与耐碱突变体多肽特异性结合的抗体，突变检测试剂盒生物样品，以及用于评估生物样品中是否存在对烷基抑制剂的抗性突变以诊断对至少一种碱性抑制剂有抗药性或可能发展出抗药性的癌症的方法。小分子激酶，用于评估生物学样品中是否具有抑制碱性磷酸酶抑制剂的突变，以诊断对患者具有抗药性或可能对pf-02341066产生抗药性的癌症，从而特异性降低抗癌突变体的表达以治疗癌症与激活抗至少一种小分子烷基激酶抑制剂的异常环路能力有关，该抑制剂治疗对pf-02341066有抵抗力的异常癌症
4. Isolated polynucleotide, methods for identifying or amplifying and genotyping all or part of a polynucleotide, for separating a polypeptide, to obtain an immunospecific antibody, for identifying an agent and a compound between one or more compounds to be tested, for analyzing the biological characteristics of a patient, to prevent or treat in an individual a disease and disorder or disease linked to the presence of polynucleotide in the genome, to increase or decrease activity in a polypeptide patient, to statistically determine relevant associations between at least one snp is a disease or disease resistance and for diagnosing or determining a disease prognosis or disease resistance, recombinant vector, host cell, polypeptide, immunospecific antibody, therapeutic agent, and compound [P] . BR0209097A . 2005-04-19

机译：分离的多核苷酸，鉴定或扩增和多核苷酸的全部或部分基因型，分离多肽，获得免疫特异性抗体，鉴定一种或多种待测化合物之间的试剂和化合物，分析其生物学特性的方法患者，以预防或治疗与基因组中多核苷酸的存在有关的疾病和病症或疾病，以增加或降低多肽患者的活性，以统计学方式确定至少一种snp是疾病或抗病性以及用于诊断或确定疾病预后或抗病性的重组载体，宿主细胞，多肽，免疫特异性抗体，治疗剂和化合物
5. Polinucleotu00eddeo insulated tape of expression, host cell, isolated transgenic non-human animal polypeptide, which has been modified to express a polypeptide mutant with resistance to ALK, antibody that binds specifically to a polypeptide mutant with resistance to ALK, kit p For detection of a mutation with resistance to ALK inhibitor in a biological sample, and,Methods for evaluating a biological sample as a mutation with resistance to ALK inhibitor, for diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to evaluate a biological sample that Anto a mutation with resistance to ALK inhibitor.For diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to assess the biological sample as a mutation with resistance to ALK inhibitor, a cancer that is resistant to dianosticar Or is likely to develop resistance to PF - 02341066 in a pati [P] . BR112012026239A2 . 2016-11-29

机译：修饰的多聚核苷酸绝缘带，宿主细胞，分离的转基因非人类动物多肽，经过修饰以表达对ALK具有抗性的多肽突变体，与对ALK具有抗性的多肽突变体特异性结合的抗体，试剂盒p用于检测生物样品中对ALK抑制剂具有抗性的突变，以及用于评估生物样品为对ALK抑制剂具有抗性的突变的方法，用于诊断对至少一种对ALK抑制剂具有抗性或可能发展出抗性的癌症激酶小分子ALK，以评估Anto对ALK抑制剂具有抗性的突变的生物样品。用于诊断对至少一种激酶小分子ALK抑制剂具有抗药性或可能产生抗性的癌症，以评估该生物样品作为对ALK抑制剂有抗性的突变，即对狄诺司他抗性或可能对PF产生抗药性的癌症-02341066