首页> 中国专利> 检测巨噬细胞中RFX1表达水平的试剂在制备巨噬细胞分型检测制剂中的应用

检测巨噬细胞中RFX1表达水平的试剂在制备巨噬细胞分型检测制剂中的应用

页面导航

摘要
著录项
相似文献

摘要

本发明公开了一种检测巨噬细胞中RFX1表达水平的试剂在制备巨噬细胞分型检测制剂中的应用。通过巨噬细胞中RFX1的表达水平判断巨噬细胞分化类型，在M1型巨噬细胞中RFX1的表达水平高于M0和M2型巨噬细胞。提示该基因可作为M1型巨噬细胞的生物标志物，在巨噬细胞的分型鉴定中具有较好的应用价值。

著录项

公开/公告号CN111500693B

专利类型发明专利
公开/公告日2020-09-22

原文格式PDF
申请/专利权人中南大学;
展开▼

申请/专利号CN202010625128.2
发明设计人贾素洁;赵明;杨爽;堵培;
展开▼

申请日2020-07-02
分类号C12Q1/6881(20180101);C12N15/11(20060101);G01N33/569(20060101);G01N33/68(20060101);
代理机构43114 长沙市融智专利事务所(普通合伙);
代理人袁靖
地址 410083 湖南省长沙市岳麓区麓山南路932号
入库时间 2022-08-23 11:14:43

相似文献

专利
中文文献
外文文献

1. 检测巨噬细胞中RFX1表达水平的试剂在制备巨噬细胞分型检测制剂中的应用 [P] . 中国专利： CN111500693B . 2020.09.22
2. 检测巨噬细胞中RFX1表达水平的试剂在制备巨噬细胞分型检测制剂中的应用 [P] . 中国专利： CN111500693A . 2020-08-07
3. Polinucleu00e0tidos isolated protein of the wall of cu00c9lula plant construu00c7u00e7o DNA, plant cells, plants transgu00canicas, sequ00dcu00cancias isolated nucleu00e0tidos, methods of produu00c7u00e7o plant transgu00canica, correlau00c7u00e7o of expressu00e7o of polinucleu00e0tido in two different samples and D. And possession of a fenu00e0tipo of plant with the level of expressu00e7o of polinucleu00e0tido in the plant of one or more polinucleu00e0tidos,Of detecu00c7u00e7o one or more polinucleu00e0tidos one sample and one or more sequ00dcu00cancias acid nuclu00c9ico encoded by one or more polinucleu00e0tidos in a sample, wood pulp, expressu00e7o combinations to detect one or more polinucleu00e0tidos, microarranjo and kit to detect the express. S call to gene. [P] . BRPI0619443A2 . 2013-01-22

机译：植物核的壁上的polinucle u00e0tidos分离蛋白构建体 u00c7 u00e7o DNA，植物细胞，植物transg u00canicas，seq u00dc u00cancias分离的核 u00e0tidos，生产方法，生产方法在两个不同的样本和D中表达polinucle u00e7o的表达。并且在一个或多个policulcle u00e0t的植物中拥有与polinucle u00e0tido的表达水平相当的植物芬。在一个样本中，一个样本或多个样本中的一个或多个，以及由一个或多个样本中的一个或多个粒子编码的seq，木浆表达检测到一个的组合。或更多个polinucle u00tidos，microarranjo和试剂盒来检测表达。呼唤基因。
4. isolated polynucleotide, expression cassette, host cell, isolated polypeptide, non-human transgenic animal that has been altered to express an alkali resistant mutant polypeptide, an antibody that specifically binds to an alkali resistant mutant polypeptide, a mutation detection kit alk inhibitor resistance in a biological sample, and methods for evaluating a biological sample for an alk inhibitor resistance mutation to diagnose cancer that is resistant to or likely to develop resistance to at least one alkaline inhibitor. small alk molecule kinase, to evaluate a biological sample for an alk inhibitor resistance mutation, to diagnose cancer that is resistant to or likely to develop resistance to pf-02341066 in a patient, to specifically reduce expression of an alk-resistant mutant to treat cancer associated with activating aberrant loop capacity that is resistant to at least one small molecule alk kinase inhibitor treating an aberrant cancer that is resistant to pf-02341066, identifyin [P] . BR112012026239A2 . 2018-06-26

机译：分离的多核苷酸，表达盒，宿主细胞，分离的多肽，已被改变以表达耐碱突变体多肽的非人类转基因动物，与耐碱突变体多肽特异性结合的抗体，突变检测试剂盒生物样品，以及用于评估生物样品中是否存在对烷基抑制剂的抗性突变以诊断对至少一种碱性抑制剂有抗药性或可能发展出抗药性的癌症的方法。小分子激酶，用于评估生物学样品中是否具有抑制碱性磷酸酶抑制剂的突变，以诊断对患者具有抗药性或可能对pf-02341066产生抗药性的癌症，从而特异性降低抗癌突变体的表达以治疗癌症与激活抗至少一种小分子烷基激酶抑制剂的异常环路能力有关，该抑制剂治疗对pf-02341066有抵抗力的异常癌症
5. Polinucleotu00ecdeos and polinucleotu00ecdeos isolated plant cells, transgenic plants, DNA construct, wood, wood pulp, methods of production of a plant transformed from wood,Pulp of wood, methods of modification of the phenotype of a plant, the correlation of the expression of genes in two different samples.The possession of a phenotype of the plant at the level of gene expression in the plant of one or more genes and correlation of gene expression with the propensity to form wood of reaction.The combination of the detection of the expression of one or more genes, microconjunto, methods for detection of one or more genes in a sample.One or more nucleic acid sequences encoded by one or more genes in a sample and kit. [P] . BRPI0406291A . 2006-05-02

机译：聚核苷酸和聚核苷酸分离的植物细胞，转基因植物，DNA构建体，木材，木浆，由木材转化的植物的生产方法，木浆，修饰植物表型的方法，相关性基因在两个不同样品中的表达。在一个或多个基因在植物中的基因表达水平上具有植物的表型，并且基因表达与形成反应木材的倾向相关。一种或多种基因的表达，微结膜，检测样品中一种或多种基因的方法。样品和试剂盒中一种或多种基因编码的一种或多种核酸序列。