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结合CS1蛋白兔重组单克隆抗体及应用

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摘要

本发明涉及结合CS1蛋白的兔重组单克隆抗体及应用，所得到的抗体具有良好的特异性，最重要的是该抗体亲和力高，具有良好的特异性，可以弥补市场上结合CS1蛋白的兔重组单克隆抗体的诊断与治疗相关的应用。

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公开/公告号CN115433278A

专利类型发明专利
公开/公告日2022-12-06

原文格式PDF
申请/专利权人苏州缔码生物科技有限公司;
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申请/专利号CN202110627995.4
发明设计人马东晖;洪淑娟;梅芬;蔡萌;
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申请日2021-06-05
分类号C07K16/28;A61K39/395;A61P35/00;G01N33/577;G01N33/574;
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地址 215163 江苏省苏州市虎丘区锦峰路8号2号楼411-6室
入库时间 2023-06-19 17:50:01

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法律状态
2022-12-06

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1. 特异性结合VCAM-1并抑制白细胞与内皮细胞之间粘附和变移的人重组单克隆抗体 [P] . 中国专利： CN102574916A . 2012-07-11
2. 与肿瘤排斥抗原前体MAGE-1结合的单克隆抗体，重组的MAGE-1，和衍生于MAGE-1的免疫原性肽 [P] . 中国专利： CN1145032A . 1997-03-12
3. isolated monoclonal antibodies; monoclonal antibodies or antigen binding fragments thereof; composition; isolated polynucleotide molecules; recombinant polypeptide; polypeptides; host cell; method of making an antibody; use of an agent for treating cancer in a patient; uses of monoclonal antibody or antigen-binding fragment thereof for the treatment of a subject suffering from cancer; use of monoclonal antibody to treat a subject suffering from cancer; a composition comprising an agr2 binding antibody; a composition comprising a c4.4a binding antibody; a composition comprising an agr2 binding antibody and a c4.4a binding antibody; composition comprising an antibody; use of an agr2 binding antibody; use of a c4.4a binding antibody; use of an antibody; and kit comprising an antibody [P] . BR112017004510A8 . 2018-06-26

机译：分离的单克隆抗体;单克隆抗体或其抗原结合片段;组成;分离的多核苷酸分子;重组多肽多肽;宿主细胞;制备抗体的方法;药剂用于治疗患者的癌症的用途;单克隆抗体或其抗原结合片段在治疗癌症患者中的用途;单克隆抗体在治疗患有癌症的受试者中的用途;包含agr2结合抗体的组合物;包含c4.4a结合抗体的组合物;包含agr2结合抗体和c4.4a结合抗体的组合物;包含抗体的组合物;使用agr2结合抗体;使用c4.4a结合抗体;抗体的使用;和包含抗体的试剂盒
4. isolated monoclonal antibodies; monoclonal antibodies or antigen binding fragments thereof; composition; isolated polynucleotide molecules; recombinant polypeptide; polypeptides; host cell; method of making an antibody; use of an agent for treating cancer in a patient; uses of monoclonal antibody or antigen-binding fragment thereof for the treatment of a subject suffering from cancer; use of monoclonal antibody to treat a subject suffering from cancer; a composition comprising an agr2 binding antibody; a composition comprising a c4.4a binding antibody; a composition comprising an agr2 binding antibody and a c4.4a binding antibody; composition comprising an antibody; use of an agr2 binding antibody; use of a c4.4a binding antibody; use of an antibody; and kit comprising an antibody [P] . BR112017004510A2 . 2018-01-23

机译：分离的单克隆抗体;单克隆抗体或其抗原结合片段;组成;分离的多核苷酸分子;重组多肽多肽;宿主细胞;制备抗体的方法;药剂用于治疗患者的癌症的用途;单克隆抗体或其抗原结合片段在治疗癌症患者中的用途;单克隆抗体在治疗患有癌症的受试者中的用途;包含agr2结合抗体的组合物;包含c4.4a结合抗体的组合物;包含agr2结合抗体和c4.4a结合抗体的组合物;包含抗体的组合物;使用agr2结合抗体;使用c4.4a结合抗体;抗体的使用;和包含抗体的试剂盒
5. isolated monoclonal antibody, isolated human monoclonal antibody, pharmaceutical composition, isolated recombinant anti-igf-i and anti-igf-ii antibody or antigen-binding fragment thereof, method for detecting factor i and factor ii of human insulin growth in a sample , method for detecting human insulin growth factor i in a sample, isolated nucleic acid, recombinant cell, host cell, method for preparing an antibody, method for preparing an antibody, method for treating neoplastic disease in a mammalian individual, method for to diagnose neoplastic disease in a mammal and method to classify a drug candidate compound [P] . BRPI0709481A2 . 2011-07-19

机译：分离的单克隆抗体，分离的人单克隆抗体，药物组合物，分离的重组抗-igf-i和抗-igf-ii抗体或其抗原结合片段，检测样品中人胰岛素生长的第i因子和第ii因子的方法，方法用于检测样品中人胰岛素生长因子i的方法，分离的核酸，重组细胞，宿主细胞，制备抗体的方法，制备抗体的方法，治疗哺乳动物个体中的肿瘤性疾病的方法，用于诊断肿瘤性疾病的方法哺乳动物和将候选药物化合物分类的方法