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一种人工多肽组合物、其抗体及在病理检测中的应用

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摘要

本发明公开了一种人工多肽组合物及其抗体和在病理检测中的应用，属于生物学检测技术领域及免疫学领域。所述人工多肽具有SEQ ID NO:1‑10任一所示氨基酸序列；或具有SEQ ID NO:11‑20任一所示氨基酸序列；或具有SEQ ID NO:21‑30任一所示氨基酸序列。利用所述人工多肽组合物及其抗体建立病理增强型二抗检测方法，稳定性高、重复性好，特别适合于表达丰度低的蛋白的检测；并且能够用于两种或多种抗原同时检测，特异性好，灵敏度高，应用前景广阔。

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公开/公告号CN112592385A

专利类型发明专利
公开/公告日2021-04-02

原文格式PDF
申请/专利权人杭州百凌生物科技有限公司;
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申请/专利号CN202011458041.7
发明设计人潘丽;李明振;蔡宁;
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申请日2020-12-10
分类号C07K7/08(20060101);C07K14/00(20060101);C07K7/06(20060101);C07K16/44(20060101);C07K19/00(20060101);G01N33/569(20060101);G01N33/58(20060101);G01N33/577(20060101);
代理机构33305 杭州信义达专利代理事务所(普通合伙);
代理人万景旺
地址 310052 浙江省杭州市滨江区长河街道滨安路688号5幢13层1303室
入库时间 2023-06-19 10:27:30

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法律状态
2023-02-03

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1. 一种人工多肽组合物、其抗体及在病理检测中的应用 [P] . 中国专利： CN112592385A . 2021-04-02
2. 一种人工多肽HM、其抗体及在病理检测中的应用 [P] . 中国专利： CN112694520A . 2021-04-23
3. isolated monoclonal antibodies; monoclonal antibodies or antigen binding fragments thereof; composition; isolated polynucleotide molecules; recombinant polypeptide; polypeptides; host cell; method of making an antibody; use of an agent for treating cancer in a patient; uses of monoclonal antibody or antigen-binding fragment thereof for the treatment of a subject suffering from cancer; use of monoclonal antibody to treat a subject suffering from cancer; a composition comprising an agr2 binding antibody; a composition comprising a c4.4a binding antibody; a composition comprising an agr2 binding antibody and a c4.4a binding antibody; composition comprising an antibody; use of an agr2 binding antibody; use of a c4.4a binding antibody; use of an antibody; and kit comprising an antibody [P] . BR112017004510A2 . 2018-01-23

机译：分离的单克隆抗体;单克隆抗体或其抗原结合片段;组成;分离的多核苷酸分子;重组多肽多肽;宿主细胞;制备抗体的方法;药剂用于治疗患者的癌症的用途;单克隆抗体或其抗原结合片段在治疗癌症患者中的用途;单克隆抗体在治疗患有癌症的受试者中的用途;包含agr2结合抗体的组合物;包含c4.4a结合抗体的组合物;包含agr2结合抗体和c4.4a结合抗体的组合物;包含抗体的组合物;使用agr2结合抗体;使用c4.4a结合抗体;抗体的使用;和包含抗体的试剂盒
4. isolated monoclonal antibodies; monoclonal antibodies or antigen binding fragments thereof; composition; isolated polynucleotide molecules; recombinant polypeptide; polypeptides; host cell; method of making an antibody; use of an agent for treating cancer in a patient; uses of monoclonal antibody or antigen-binding fragment thereof for the treatment of a subject suffering from cancer; use of monoclonal antibody to treat a subject suffering from cancer; a composition comprising an agr2 binding antibody; a composition comprising a c4.4a binding antibody; a composition comprising an agr2 binding antibody and a c4.4a binding antibody; composition comprising an antibody; use of an agr2 binding antibody; use of a c4.4a binding antibody; use of an antibody; and kit comprising an antibody [P] . BR112017004510A8 . 2018-06-26

机译：分离的单克隆抗体;单克隆抗体或其抗原结合片段;组成;分离的多核苷酸分子;重组多肽多肽;宿主细胞;制备抗体的方法;药剂用于治疗患者的癌症的用途;单克隆抗体或其抗原结合片段在治疗癌症患者中的用途;单克隆抗体在治疗患有癌症的受试者中的用途;包含agr2结合抗体的组合物;包含c4.4a结合抗体的组合物;包含agr2结合抗体和c4.4a结合抗体的组合物;包含抗体的组合物;使用agr2结合抗体;使用c4.4a结合抗体;抗体的使用;和包含抗体的试剂盒
5. use of low density oxidized lipoprotein immunotherapy, method for inducing regression of atherosclerotic plaques in an individual, use of at least one ldl antibody or at least one oxidized epitope of ldl, method for combating cardiovascular disease associated with atherosclerosis, use of at least an antibody molecule or at least one oxidized epitope of ldl and a statin, pharmaceutical formulation, part kit, methods for identifying an antibody that induces regression of atherosclerotic plaques in an individual and for identifying an agent that induces regression of atherosclerotic plaques in an individual, antibody, pharmaceutical composition, and antibody use [P] . BRPI0615313A2 . 2012-12-04

机译：低密度氧化脂蛋白免疫疗法的应用，在个体中诱导动脉粥样硬化斑块消退的方法，至少一种ldl抗体或ldl的至少一种氧化表位的使用，与动脉粥样硬化相关的心血管疾病的防治方法，至少一种抗体的使用分子和至少一种Idl的氧化表位和他汀类药物，药物制剂，部分试剂盒，鉴定在个体中诱导动脉粥样硬化斑块消退的抗体和鉴定在个体中诱导动脉粥样硬化斑块消退的药剂的方法，抗体，药物组合物和抗体用途