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用于治疗与帕金森氏病有关的症状的化合物

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摘要

本发明涉及一种包含用于治疗、预防和/或改善帕金森氏病运动症状的肽的化合物，所述肽能结合特异于淀粉样蛋白β肽(Aβ)的表位的抗体。

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公开/公告号CN102123726A

专利类型发明专利
公开/公告日2011-07-13

原文格式PDF
申请/专利权人阿费里斯股份公司;
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申请/专利号CN200980131367.4
发明设计人马库斯·曼德勒;弗兰克·马特纳;沃尔特·施密特;
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申请日2009-06-12
分类号A61K38/08(20060101);A61P25/16(20060101);A61P25/28(20060101);C07K16/18(20060101);
代理机构11105 北京市柳沈律师事务所;
代理人闵丹
地址奥地利维也纳
入库时间 2023-12-18 03:00:25

法律信息

法律状态公告日

法律状态信息

法律状态
2015-07-01

发明专利申请公布后的视为撤回 IPC(主分类):A61K38/08 申请公布日:20110713 申请日:20090612

发明专利申请公布后的视为撤回
2011-08-24

实质审查的生效 IPC(主分类):A61K38/08 申请日:20090612

实质审查的生效
2011-07-13

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1. 用于治疗与帕金森氏病有关的症状的化合物 [P] . 中国专利： CN102123726A . 2011-07-13
2. 用于确定锥体外系症状特别是帕金森氏病的运动症状的装置和相关方法 [P] . 中国专利： CN110494077A . 2019-11-22
3. "method of reducing the rate of progression of parkinson's disease in an early stage parkinson's disease patient, method of reducing the rate of progression of parkinson's disease, method of delaying the need for symptomatic antiparkinsonian therapy in a patient of early-stage parkinson's, risk-reduction method for a parkinson's disease patient requiring antiparkinsonian therapy, early-stage parkinson's disease reduction method, functional-decline method for a patient with Parkinson's disease, a patient's treatment method that displays early signs of parkinson's disease, fatigue reduction method in an early-stage parkinson's disease patient, method of reducing the rate of clinical progression, and treatment of symptoms of parkinsonian disease. parkinson in a patient with parkinson's disease, rasagiline or a pharmaceutically acceptable salt of rasagiline, pharmaceutical composition. [P] . BRPI0909894A2 . 2015-07-28

机译： “降低早期帕金森氏病患者帕金森氏病进展速度的方法，降低帕金森氏病进展速度的方法，延迟对早期帕金森氏病患者进行对症抗帕金森病治疗的方法，风险-需要抗帕金森病治疗的帕金森氏病患者的缓解方法，帕金森氏病早期缓解方法，帕金森氏病患者的功能下降方法，显示帕金森氏病早期迹象的患者治疗方法，早期缓解疲劳的方法帕金森氏病患者，降低临床进展速度的方法和帕金森氏病症状的治疗帕金森氏症，雷沙吉兰或雷沙吉兰可药用盐的患者，药物组合物。
4. Compound, pharmaceutical compositions, process for treating depression, anxiety, psychosis, parkinson's disease, obesity, hypertension, tourette's syndrome, sexual dysfunction, drug addiction, drug abuse, cognitive disorders, alzheimer's disease, senile dementia, obsessive-compulsive behavior , panic attacks, eating ailments, anorexia, cardiovascular and cerebrovascular disorders, migraine, non-insulin dependent diabetes mellitus, hyperglycemia, constipation, arrhythmia, disorders of the neuroendocrine system, tension, prostatic hypertrophy, extrapyramidal symptoms induced by drugs or spasticity, use of a compound, and, process for preparing the compound [P] . BR9910927A . 2001-02-20

机译：化合物，药物组合物，治疗抑郁症，焦虑症，精神病，帕金森氏病，肥胖症，高血压，抽动秽语综合征，性功能障碍，吸毒成瘾，药物滥用，认知障碍，阿尔茨海默氏病，老年性痴呆，强迫症，惊恐发作，饮食疾病，厌食症，心脑血管疾病，偏头痛，非胰岛素依赖型糖尿病，高血糖，便秘，心律不齐，神经内分泌系统疾病，紧张，前列腺肥大，药物或痉挛引起的锥体外系症状，使用化合物以及，化合物的制备方法
5. compound of formula i; pharmaceutical composition; method of treating disorders that are related to or affected by inhibition of norepinephrine reuptake, the 5-ht6 receptor or the 5-ht2a receptor; a method of treating a learning disorder, a cognitive disorder, a memory disorder, a personality disorder, a behavioral disorder, a movement disorder, a neurodegenerative disorder, drug withdrawal disorder, sleep, an eating disorder, acute drug toxicity, a cardiovascular disorder, a sexual dysfunction, a gastrointestinal disorder, a genitourinary disorder, a pain disorder, a nervous disorder or a symptom disorder vasomotor; method of treating alzheimer's disease, attention deficit disorder, schizophrenia, parkinson's disease, tardive dyskinesia, ataxia, bradykinesia, paroxysmal dyskinesias, restless leg syndrome, tremor, essential tremor epilepsy, stroke or head trauma; method of treating coronary artery disease, myocardial infarction, transient ischemic attack, angina, atrial fibrillation, p [P] . BRPI0706523A2 . 2011-01-04

机译：式I化合物;药物组合物;治疗与去甲肾上腺素再摄取，5-ht6受体或5-ht2a受体相关或受其抑制的疾病的方法;一种治疗学习障碍，认知障碍，记忆障碍，人格障碍，行为障碍，运动障碍，神经退行性疾病，戒断药物，睡眠，进食障碍，急性药物毒性，心血管疾病的方法，性功能障碍，胃肠道疾病，泌尿生殖系统疾病，疼痛疾病，神经疾病或症状-血管舒缩;治疗阿尔茨海默氏病，注意力缺陷障碍，精神分裂症，帕金森氏病，迟发性运动障碍，共济失调，运动迟缓，阵发性运动障碍，不安腿综合征，震颤，原发性震颤癫痫，中风或头部外伤的方法;治疗冠状动脉疾病，心肌梗塞，短暂性脑缺血发作，心绞痛，心房颤动，p的方法