首页> 中国专利> 用于靶向癌症的IL－17拮抗性抗体

用于靶向癌症的IL－17拮抗性抗体

页面导航

摘要
著录项
法律信息
相似文献

摘要

本发明提供了用于治疗实体或者造血系统恶性疾病的IL－17结合分子，特别是人IL－17的抗体，更特别是人IL－7的人抗体，其中重链和轻链的高变区具有所定义的氨基酸序列。

著录项

公开/公告号CN101374864A

专利类型发明专利
公开/公告日2009-02-25

原文格式PDF
申请/专利权人诺瓦提斯公司;
展开▼

申请/专利号CN200780003925.X
发明设计人 M·科勒曼;F·E·迪帕多瓦;
展开▼

申请日2007-01-30
分类号C07K16/24;
代理机构北京市中咨律师事务所;
代理人黄革生
地址瑞士巴塞尔
入库时间 2023-12-17 21:27:57

法律信息

法律状态公告日

法律状态信息

法律状态
2012-05-30

发明专利申请公布后的视为撤回 IPC(主分类):C07K16/24 公开日:20090225 申请日:20070130

发明专利申请公布后的视为撤回
2009-04-22

实质审查的生效

实质审查的生效
2009-02-25

公开

公开

相似文献

专利
中文文献
外文文献

1. 用于靶向癌症的IL－17拮抗性抗体 [P] . 中国专利： CN101374864A . 2009-02-25
2. 用于治疗癌症的一种或多种包含靶向掩蔽I型干扰素(IFNA和IFNB)和针对肿瘤抗原的抗体的融合蛋白组合物 [P] . 中国专利： CN113993540A . 2022-01-28
3. Polinucleotu00eddeo insulated tape of expression, host cell, isolated transgenic non-human animal polypeptide, which has been modified to express a polypeptide mutant with resistance to ALK, antibody that binds specifically to a polypeptide mutant with resistance to ALK, kit p For detection of a mutation with resistance to ALK inhibitor in a biological sample, and,Methods for evaluating a biological sample as a mutation with resistance to ALK inhibitor, for diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to evaluate a biological sample that Anto a mutation with resistance to ALK inhibitor.For diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to assess the biological sample as a mutation with resistance to ALK inhibitor, a cancer that is resistant to dianosticar Or is likely to develop resistance to PF - 02341066 in a pati [P] . BR112012026239A2 . 2016-11-29

机译：修饰的多聚核苷酸绝缘带，宿主细胞，分离的转基因非人类动物多肽，经过修饰以表达对ALK具有抗性的多肽突变体，与对ALK具有抗性的多肽突变体特异性结合的抗体，试剂盒p用于检测生物样品中对ALK抑制剂具有抗性的突变，以及用于评估生物样品为对ALK抑制剂具有抗性的突变的方法，用于诊断对至少一种对ALK抑制剂具有抗性或可能发展出抗性的癌症激酶小分子ALK，以评估Anto对ALK抑制剂具有抗性的突变的生物样品。用于诊断对至少一种激酶小分子ALK抑制剂具有抗药性或可能产生抗性的癌症，以评估该生物样品作为对ALK抑制剂有抗性的突变，即对狄诺司他抗性或可能对PF产生抗药性的癌症-02341066
4. isolated polynucleotide, expression cassette, host cell, isolated polypeptide, non-human transgenic animal that has been altered to express an alkali resistant mutant polypeptide, an antibody that specifically binds to an alkali resistant mutant polypeptide, a mutation detection kit alk inhibitor resistance in a biological sample, and methods for evaluating a biological sample for an alk inhibitor resistance mutation to diagnose cancer that is resistant to or likely to develop resistance to at least one alkaline inhibitor. small alk molecule kinase, to evaluate a biological sample for an alk inhibitor resistance mutation, to diagnose cancer that is resistant to or likely to develop resistance to pf-02341066 in a patient, to specifically reduce expression of an alk-resistant mutant to treat cancer associated with activating aberrant loop capacity that is resistant to at least one small molecule alk kinase inhibitor treating an aberrant cancer that is resistant to pf-02341066, identifyin [P] . BR112012026239A2 . 2018-06-26

机译：分离的多核苷酸，表达盒，宿主细胞，分离的多肽，已被改变以表达耐碱突变体多肽的非人类转基因动物，与耐碱突变体多肽特异性结合的抗体，突变检测试剂盒生物样品，以及用于评估生物样品中是否存在对烷基抑制剂的抗性突变以诊断对至少一种碱性抑制剂有抗药性或可能发展出抗药性的癌症的方法。小分子激酶，用于评估生物学样品中是否具有抑制碱性磷酸酶抑制剂的突变，以诊断对患者具有抗药性或可能对pf-02341066产生抗药性的癌症，从而特异性降低抗癌突变体的表达以治疗癌症与激活抗至少一种小分子烷基激酶抑制剂的异常环路能力有关，该抑制剂治疗对pf-02341066有抵抗力的异常癌症
5. Nucleic acids that target TCTP for use in the treatment of chemoresistant or hormone-resistant cancers [P] . ES2710109T3 . 2019-04-23

机译：靶向TCTP的核酸用于治疗化学抗性或激素抗性癌症