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一种抑制PLGA微球中多肽类药物酰化副反应的方法

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摘要

本发明公开一种抑制PLGA微球中多肽类药物酰化副反应的方法。该方法针对工业化中应用最广泛的微球制备方法—乳化溶剂挥发法，通过在复乳制备过程中添加一类特殊的二价金属盐的方式，达到长期抑制多肽与载体发生的酰化副反应的目的。所述的二价金属盐具有如下特征：1）难溶于水；2）能够吸纳微球降解产生的氢离子（H

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公开/公告号CN110090293A

专利类型发明专利
公开/公告日2019-08-06

原文格式PDF
申请/专利权人南京工业大学;
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申请/专利号CN201910387385.4
发明设计人李学明;刘吉伟;王永禄;任浩;孟政杰;徐妍;陈卫;王栋;李杨;
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申请日2019-05-10
分类号
代理机构南京汇恒知识产权代理事务所(普通合伙);
代理人王月霞
地址 211816 江苏省南京市江北新区浦珠南路30号
入库时间 2024-02-19 11:14:07

法律信息

法律状态公告日

法律状态信息

法律状态
2019-08-30

实质审查的生效 IPC(主分类):A61K38/08 申请日:20190510

实质审查的生效
2019-08-06

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1. 一种抑制PLGA微球中多肽类药物酰化副反应的方法 [P] . 中国专利： CN110090293A . 2019-08-06
2. 一种蛋白多肽类药物双重微球及其制备方法和胰岛素双重微球 [P] . 中国专利： CN109568601B . 2021.08.24
3. isolated polynucleotide, expression cassette, host cell, isolated polypeptide, non-human transgenic animal that has been altered to express an alkali resistant mutant polypeptide, an antibody that specifically binds to an alkali resistant mutant polypeptide, a mutation detection kit alk inhibitor resistance in a biological sample, and methods for evaluating a biological sample for an alk inhibitor resistance mutation to diagnose cancer that is resistant to or likely to develop resistance to at least one alkaline inhibitor. small alk molecule kinase, to evaluate a biological sample for an alk inhibitor resistance mutation, to diagnose cancer that is resistant to or likely to develop resistance to pf-02341066 in a patient, to specifically reduce expression of an alk-resistant mutant to treat cancer associated with activating aberrant loop capacity that is resistant to at least one small molecule alk kinase inhibitor treating an aberrant cancer that is resistant to pf-02341066, identifyin [P] . BR112012026239A2 . 2018-06-26

机译：分离的多核苷酸，表达盒，宿主细胞，分离的多肽，已被改变以表达耐碱突变体多肽的非人类转基因动物，与耐碱突变体多肽特异性结合的抗体，突变检测试剂盒生物样品，以及用于评估生物样品中是否存在对烷基抑制剂的抗性突变以诊断对至少一种碱性抑制剂有抗药性或可能发展出抗药性的癌症的方法。小分子激酶，用于评估生物学样品中是否具有抑制碱性磷酸酶抑制剂的突变，以诊断对患者具有抗药性或可能对pf-02341066产生抗药性的癌症，从而特异性降低抗癌突变体的表达以治疗癌症与激活抗至少一种小分子烷基激酶抑制剂的异常环路能力有关，该抑制剂治疗对pf-02341066有抵抗力的异常癌症
4. Polinucleotu00eddeo insulated tape of expression, host cell, isolated transgenic non-human animal polypeptide, which has been modified to express a polypeptide mutant with resistance to ALK, antibody that binds specifically to a polypeptide mutant with resistance to ALK, kit p For detection of a mutation with resistance to ALK inhibitor in a biological sample, and,Methods for evaluating a biological sample as a mutation with resistance to ALK inhibitor, for diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to evaluate a biological sample that Anto a mutation with resistance to ALK inhibitor.For diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to assess the biological sample as a mutation with resistance to ALK inhibitor, a cancer that is resistant to dianosticar Or is likely to develop resistance to PF - 02341066 in a pati [P] . BR112012026239A2 . 2016-11-29

机译：修饰的多聚核苷酸绝缘带，宿主细胞，分离的转基因非人类动物多肽，经过修饰以表达对ALK具有抗性的多肽突变体，与对ALK具有抗性的多肽突变体特异性结合的抗体，试剂盒p用于检测生物样品中对ALK抑制剂具有抗性的突变，以及用于评估生物样品为对ALK抑制剂具有抗性的突变的方法，用于诊断对至少一种对ALK抑制剂具有抗性或可能发展出抗性的癌症激酶小分子ALK，以评估Anto对ALK抑制剂具有抗性的突变的生物样品。用于诊断对至少一种激酶小分子ALK抑制剂具有抗药性或可能产生抗性的癌症，以评估该生物样品作为对ALK抑制剂有抗性的突变，即对狄诺司他抗性或可能对PF产生抗药性的癌症-02341066
5. insecticidal polypeptide, insecticidal composition, recombinant polynucleotide, dna construct, plant cell or transgenic plant, method for inhibiting growth or exterminating an agricultural insect pest population, method for inhibiting growth or exterminating an insect pest, method for controlling lepidoptera and / or coleoptera insect infestation in a transgenic plant and provide insect resistance management and use of at least one insecticide polypeptide [P] . BR112019008800A2 . 2019-07-16

机译：杀虫多肽，杀虫组合物，重组多核苷酸，dna构建体，植物细胞或转基因植物，抑制生长或消灭农业害虫种群的方法，抑制生长或消灭害虫的方法，防治鳞翅目和/或鞘翅目昆虫侵害的方法转基因植物中的抗性，并提供抗虫性管理和至少一种杀虫剂多肽的用途