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Sex differences in opioid analgesia and addiction: Interactions among opioid receptors and estrogen receptors

机译:阿片类药物镇痛和成瘾的性别差异:阿片类药物受体和雌激素受体之间的相互作用

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摘要

[[abstract]]Opioids are widely used as the pain reliever and also notorious for being addictive drugs. Sex differences in the opioid analgesia and addiction have been reported and investigated in human subjects and animal models. Yet, the molecular mechanism underlying the differences between males and females is still unclear. Here, we reviewed the literature describing the sex differences in analgesic responses and addiction liabilities to clinically relevant opioids. The reported interactions among opioids, estrogens, opioid receptors, and estrogen receptors are also evaluated. We postulate that the sex differences partly originated from the crosstalk among the estrogen and opioid receptors when stimulated by the exogenous opioids, possibly through common secondary messengers and the downstream gene transcriptional regulators.
机译:[[摘要]]阿片类药物被广泛用作止痛药,并且以成瘾性药物而臭名昭著。阿片类药物镇痛和成瘾的性别差异已在人类受试者和动物模型中得到报道和调查。然而,男女差异背后的分子机制仍不清楚。在这里,我们回顾了描述镇痛反应和对临床相关阿片类药物成瘾倾向的性别差异的文献。还评估了阿片类药物,雌激素,阿片类药物受体和雌激素受体之间相互作用的报道。我们推测,性别差异部分是由外源阿片类药物刺激时雌激素和阿片类药物受体之间的串扰引起的,可能是通过常见的次级信使和下游基因转录调节因子引起的。

著录项

  • 作者

    Lee, CWS;

  • 作者单位
  • 年度 2013
  • 总页数
  • 原文格式 PDF
  • 正文语种 en-US
  • 中图分类
  • 入库时间 2022-08-20 20:13:40

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