Low Dose Furazolidone for Eradication of H- pylori Instead ofudClarithromycin: A Clinical Trial

摘要

Background: Helicobacter pylori infection is a common chronic human bacterial infection. Triple- therapyudregimen containing a proton pump inhibitor, clarithromycin, and either amoxicillin or metronidazole isudcommonly used as first-line treatment for its eradication. However, it may not provide the acceptable eradicationudrate. The present study was designed to evaluated efficacy of low dose furazolidone with amoxicillin andudomeprazole for eradication of H- pylori.udMaterials and Methods: One hundred twenty patients with non- ulcer dyspepsia or peptic ulcer confirmed byudupper GI endoscopy, plus H- pylori infection confirmed by rapid urease test were included in the study. Theyudwere randomly divided into two groups, and then received clarithromycin, amoxicillin, and omeprazole, orudfurazolidone (100 mg PO bid), amoxicillin, and omeprazole. They were evaluated using urea breath test at theudend of the study.udFindings: The eradication rates were 57.6% and 78.8% in clarithromycin and furazolidone groups, respectively.udTheir difference was statistically significant (P value 0.013). No side effect was seen in the furazolidone group.udConclusion: Low dose furazolidone rather than clarithromycin can be used as low- cost and effective drug foruderadication of H- pylori, in combination with amoxicillin and omeprazole.udKeywords: Helicobacter pylori, furazolidone, non- ulcer dyspepsia, peptic ulcer