OBJECTIVE:udTo evaluate the diagnostic accuracy of intracranial translucency (IT) in the detection of spina bifida (SB) in the first trimester of pregnancy.ududMETHODS:udWe included study assessing the accuracy of sonographic measurements of IT in a mid-sagittal view of the fetal face in prediction of SB in the first trimester of pregnancy. The primary outcome was the accuracy of IT in prediction of spina bifida. Summary estimates of sensitivity, specificity, positive and negative likelihood ratios (LR), and diagnostic odds ratio for the overall predictive accuracy of IT were computed.ududRESULTS:udNine studies (21 070 fetuses) were included in the analysis. IT was successfully assessed in the majority of fetuses 97.8% (95% CI 97.6-98.0). The diagnostic performance of IT in detecting SB was as follows: sensitivity: 53.5% (95% CI 42.4-64.3), specificity: 99.7% (95% CI 99.6-99.8), positive LR: 62.1 (95% CI 12.2-317), negative LR:0.55 (95% CI 0.45-0.68), and diagnostic odds ratio: 223 (95% CI 25-2039).ududCONCLUSIONS:udIntracranial translucency had low diagnostic accuracy in prediction of open spina bifida, thus questioning its role as a screening marker for open SB in an unselected population. When looking at the individual study data, it appears that IT assessment for open SB prediction can be affected by a high rate of false positive results potentially leading to unnecessary parental anxiety
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机译：目的： ud为了评估颅内半透明（IT）在妊娠前三个月检测脊柱裂（SB）的诊断准确性。 ud ud方法： ud我们纳入了一项研究，旨在评估中期超声对超声检查的准确性预测怀孕前三个月的SB胎面矢状图。主要结果是IT预测脊柱裂的准确性。计算了IT整体预测准确性的敏感性，特异性，阳性和阴性似然比（LR）和诊断比值比的简要估计值。 ud ud结果： udNine研究（21〜070胎）包括在分析中。大多数胎儿的IT成功评估为97.8％（95％CI 97.6-98.0）。 IT在检测SB中的诊断性能如下：敏感性：53.5％（95％CI 42.4-64.3），特异性：99.7％（95％CI 99.6-99.8），LR阳性：62.1（95％CI 12.2-317） ，负LR：0.55（95％CI 0.45-0.68）和诊断比值比：223（95％CI 25-2039）。 ud ud结论： ud颅内半透明性在预测开放性脊柱裂中的诊断准确性较低，因此令人质疑其作为未选择人群中开放SB的筛选标志物的作用。当查看单个研究数据时，似乎开放式SB预测的IT评估可能会受到较高的假阳性结果的影响，从而可能导致不必要的父母焦虑
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