STRUCTURE AND STEREOCHEMISTRY OF (24R)-27-NOR-5-ALPHA-CHOLESTANE-3-BETA,4-BETA,5,6-ALPHA,7-BETA,8,14,15-ALPHA,24-NONAOL - A HIGHLY HYDROXYLATED MARINE STEROID FROM THE STARFISH ARCHASTER-TYPICUS

摘要

The crystal structure of the title compd. (I) was detd. The results confirm the structure previously assigned on the basis of chem. and spectroscopic evidence including the chirality at C(20) and C(24). This steroid presents a marked amphiphilic character with the nine hydroxyl groups all grouped on one side of the mol. and shows an internal hydrogen bond between the hydroxyl substituents at C(7) and C(15). In the crystal double layers of mols., internally linked by an extensive network of hydrogen bonds, interact through their hydrophobic surfaces.