Optimization of chemical reagent storage and distribution at Novartis Institutes for BioMedical Research

摘要

The Novartis Institutes for BioMedical Research is the drug discovery arm of Novartis Pharmaceuticals. Drug discovery is generally considered to be the primary driver for success in the pharmaceutical industry. Success in the early stages of drug discovery relies on dependable, innovative, disease related high-throughput screening of biological compounds and the creation of a screening deck of highly diverse, proprietary chemical compounds. In contrast with many of its peers, Novartis relies strongly on combinatorial chemistry to populate its screening deck. The Chemical Libraries (CLI) group is responsible for this approach at Novartis and delivers more than 100,000 compounds per year to the Novartis Compound Archive. Since the introduction of high-throughput screening and combinatorial chemistry techniques, the bottleneck in many drug discovery processes has shifted to the roles that support these high-volume techniques. The aim of this thesis is to provide a general collection of short and long-term suggestions for process improvement in the chemical supply process. This process includes compound search and ordering, order fulfillment, and compound delivery, was investigated.