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A miniature, implantable wireless neural stimulation system

机译:微型植入式无线神经刺激系统

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摘要

In this thesis, I present the design of a wireless neural stimulation system. The system consists of an external transmitter, controllable through a computer interface, and a miniature, implantable wireless receiver and stimulator. The implant is tailored for use in zebra finches - small birds weighing just 12-15g - as part of ongoing research into the neural mechanisms of sequence generation and learning. The implant, assembled on a miniature printed circuit board, contains a receiver coil, battery, electrodes, and a custom integrated circuit for data demodulation and neural stimulation. The chip, fabricated in a standard 0.5[mu]m CMOS process, is capable of delivering biphasic current pulses to 4 addressable electrode sites at 16 selectable current levels ranging from 100[mu]A to mA. Additionally, the biphasic pulses may be inverted. The entire implant weighs less than 1.5g and occupies a footprint smaller than 1.5cm2. A miniaturized neural stimulator such as this one also has applications in neural prostheses for blindness, Parkinson's disease, and paralysis.
机译:在本文中,我提出了一种无线神经刺激系统的设计。该系统包括一个可通过计算机接口控制的外部发射器,以及一个可植入的微型无线接收器和刺激器。该植入物是专为斑马雀而设计的-重量仅为12-15g的小鸟-是正在进行的有关序列产生和学习的神经机制研究的一部分。植入物组装在微型印刷电路板上,包含接收器线圈,电池,电极和用于数据解调和神经刺激的定制集成电路。以标准的0.5μmCMOS工艺制造的芯片能够以范围从100μA至mA的16种可选电流水平将双相电流脉冲传递到4个可寻址电极位置。另外,双相脉冲可以被反转。整个植入物的重量不到1.5g,占用的空间小于1.5cm2。诸如此类的小型神经刺激器也可用于失明,帕金森氏病和瘫痪的神经假体。

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