Studies on the synthesis of cyclohexynes for inter- and intramolecular cycloaddition reactions

摘要

Strained cycloalkynes have been of interest to organic chemists for many years due to their exotic structure and their potential utility as synthetic building blocks. This thesis examines the generation of cyclohexyne derivatives and their reactivity in inter- and intramolecular cycloadditions. Several strategies were investigated to generate substrates for the intramolecular trapping of the cyclohexynes. In addition, simple cyclohexyne derivatives were prepared and two cases of intermolecular trapping are reported.