Purpose: To report a case of non-Descemet Stripping Automated Endothelial Keratoplasty (nDSAEK) using heads-up surgery. Case/Intervention: The case was a 72-years-old man who had history of left eye blunt trauma since childhood. One year ago, the patient was diagnosed to have left posttraumatic bullous keratopathy. The patient underwent lt nDSAEK by using the heads-up three-dimensional (3D) system last July. The surgery was performed with a Rescan 700 surgical microscope (Carl Zeiss), which is integrated with intraoperative optical coherence tomography (iOCT) system. During surgery, the surgeon and audience wore 3D passive polarized glasses. A 42 inch high-definition (HD) display and 2 HD cameras (Sony) were used. With this 3D system, the nDSAEK procedure before the graft insertion into the anterior chamber was easy especially with available high magnification. Also, using iOCT of the system enables the surgeon to detect any residual fluid at the donor graft-recipient interface and locate its place to be drained. The only disadvantage of the system was the difficulty in the detection of nDSAEK graft depth in the anterior chamber, which required frequent focus change during the surgery. Although the surgeon frequently adjusted the focus for clear stereoscopic view of the graft, he did not feel any eye strain or discomfort. All other steps of the procedure were performed without any problem and postoperative course of the patient was good. Conclusion: Using heads-up surgery for performing anterior segment surgeries is encouraging and promising.
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