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Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans

机译:来自macrocystis pyrifera的褐藻糖胶与其他三种褐藻糖胶相比具有强大的免疫调节作用

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摘要

Fucoidan, a sulfated polysaccharide purified from brown algae, has a variety of immune-modulation effects, such as promoting activation of dendritic cells (DCs), natural killer (NK) cells and T cells, and enhancing anti-viral and anti-tumor responses. However, the immune-modulatory effect of fucoidan from different seaweed extracts has not been thoroughly analyzed and compared. We analyzed fucoidans obtained from Ascophyllum nodosum (A. nodosum), Macrocystis pyrifera (M. pyrifera), Undaria pinnatifida (U. pinnatifida) and Fucus vesiculosus (F. vesiculosus) for their effect on the apoptosis of human neutrophils, activation of mouse NK cells, maturation of spleen DCs, proliferation and activation of T cells, and the adjuvant effect in vivo. Fucoidans from M. pyrifera and U. pinnatifida strongly delayed human neutrophil apoptosis at low concentration, whereas fucoidans from A. nodosum and F. vesiculosus delayed human neutrophil apoptosis at higher concentration. Moreover, fucoidan from M. pyrifera promoted NK cell activation and cytotoxic activity against YAC-1 cells. In addition, M. pyrifera fucoidan induced the strongest activation of spleen DCs and T cells and ovalbumin (OVA) specific immune responses compared to other fucoidans. These data suggest that fucoidan from M. pyrifera can be potentially useful as a therapeutic agent for infectious diseases, cancer and an effective adjuvant for vaccine.
机译:Fucoidan是一种从褐藻中纯化的硫酸化多糖,具有多种免疫调节作用,例如促进树突状细胞(DC),自然杀伤(NK)细胞和T细胞的活化,并增强抗病毒和抗肿瘤反应。然而,尚未对来自不同海藻提取物的岩藻依聚糖的免疫调节作用进行彻底的分析和比较。我们分析了从Ascophyllum nodosum(A. nodosum),Macrocystis pyrifera(M. pyrifera),Pundatifida Undaria(U. pinnatifida)和Fusus vesiculosus(F. vesiculosus)获得的岩藻依聚糖对人中性粒细胞凋亡,小鼠NK活化的影响。细胞,脾脏DC的成熟,T细胞的增殖和活化以及体内佐剂作用。在较低浓度下,来自火棘分枝杆菌和pinnatifida的岩藻多糖强烈延缓了人类嗜中性粒细胞的凋亡,而在较高浓度下,来自结节曲霉和褐葡萄球菌的岩藻聚糖延迟了人类嗜中性粒细胞的凋亡。此外,来自火棘分枝杆菌的岩藻依聚糖促进了NK细胞活化和针对YAC-1细胞的细胞毒性活性。此外,与其他岩藻依聚糖相比,萤火虫岩藻依聚糖有效诱导脾脏DC和T细胞以及卵清蛋白(OVA)特异性免疫反应的最强活化。这些数据表明,来自火棘分枝杆菌的岩藻依聚糖可以潜在地用作传染病,癌症的治疗剂和疫苗的有效佐剂。

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