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Advanced light sculpting for contemporary biophotonics

机译:先进的光雕刻为当代生物光子学

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摘要

Our proprietary Generalized Phase Contrast (GPC) method is a light efficient approach for generating speckle-­‐free contiguous optical distributions using binary-­‐only or analog spatial phase modulation. It has been used in applications such as optical trapping and manipulation, active microscopy, structured illumination, optical security, parallel laser marking and recently in contemporary biophotonics applications such as for real-­‐time parallel two-­‐photon optogenetics and neurophotonics. Our most recent GPC light sculpting developments geared towards these applications will be presented. This includes both a static and a dynamic GPC Light Shaper implementation based on our latest theoretical derivations to demonstrate the benefits for typical applications where lasers have to be actively shaped into particular light patterns. We then show the potential of GPC for biomedical and multispectral applications where we experimentally demonstrate the active light shaping of a supercontinuum laser over most of the visible wavelength range.
机译:我们专有的广义相位对比(GPC)方法是一种光有效的方法,可使用仅二进制或模拟空间相位调制来生成无斑点的连续光学分布。它已被用于光学捕获和操纵,有源显微镜,结构照明,光学安全性,并行激光打标等应用,最近还被用于当代生物光子学应用,例如实时-平行双­光子光遗传学和神经光子学。我们将介绍针对这些应用的最新GPC灯光雕刻技术。这包括基于我们最新理论推导的静态和动态GPC光整形器实施方案,以展示必须将激光器主动成形为特定光图案的典型应用的好处。然后,我们展示了GPC在生物医学和多光谱应用中的潜力,其中我们通过实验证明了在大多数可见波长范围内超连续谱激光器的有源光整形。

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