Recent epidemiological studies show a positive association between cancer incidence and high intake of processed meat. N-nitrosamines (NAs) in these products have been suggested as one potential causative factor. Most volatile NAs (VNAs) are classified as probable human carcinogens, whereas the carcinogenicity for the majority of the non-volatile NA (NVNA) remains to be elucidated. Danish adults (15–75 years) and children (4–6 years) consume 20 g and 16 g of processed meat per day (95th percentile), respectively. The consumption is primarily accounted for by sausages, salami, pork flank (spiced and boiled) and ham. This consumption results in an exposure to NVNA of 33 and 90 ng kg bw−1 day−1 for adults and children, respectively. The exposure to VNA is significantly lower amounting to 0.34 and 1.1 ng kg bw−1 day−1 for adults and children, respectively. Based on a BMDL10 of 29 µg kg bw−1 day−1 a MOE value ≥17,000 was derived for the exposure to NA known to be carcinogenic (VNA including NSAR), indicating an exposure of low concern. The exposure to the NVNA is substantially higher and if found to be of toxicological significance the exposure may be of concern.
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机译：最近的流行病学研究表明，癌症发病率与加工肉的高摄入量之间呈正相关。这些产品中的N-亚硝胺（NAs）被认为是一种潜在的病因。大多数挥发性NA（VNA）被归类为可能的人类致癌物，而大多数非挥发性NA（NVNA）的致癌性仍有待阐明。丹麦成年人（15-75岁）和儿童（4-6岁）每天分别消耗20克和16克加工肉（95％）。消费主要由香肠，萨拉米香肠，猪肋骨（加香料和煮熟）和火腿组成。这种消耗导致成人和儿童分别暴露于33和90 ng kg bw-1 day-1的NVNA。成人和儿童的VNA暴露量显着降低，分别为0.34和1.1 ng kg bw-1 day-1。基于29 µg kg bw-1天-1的BMDL10，对于已知致癌的NA（包括NSAR的VNA）暴露，MOE值≥17,000。 NVNA的暴露量要高得多，如果发现具有毒理学意义，则可能会引起关注。
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