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Three-Dimensional Numerical Modeling of Acoustic Trapping in Glass Capillaries

机译:玻璃毛细管声捕获的三维数值模拟

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摘要

Acoustic traps are used to capture and handle suspended microparticles and cells in microfluidic applications. A particular simple and much-used acoustic trap consists of a commercially available, millimeter-sized, liquid-filled straight glass capillary actuated by a piezoelectric transducer. Here, we present a three-dimensional numerical model of the acoustic pressure field in the liquid coupled to the displacement field of the glass wall, taking into account mixed standing and traveling waves as well as absorption. The model explains the dynamical mechanism that leads to the formation of localized acoustic resonance modes in such a straight acoustic waveguide without any geometrical cavities in the axial direction of the capillary. The model further predicts that some of these modes are well suited for acoustic trapping, and it provides estimates for their frequencies and quality factors, the magnitude of the acoustic radiation force on a single test particle as a function of position, and the resulting acoustic retention force of the trap. We show that the model predictions are in agreement with published experimental results, and we discuss how improved and more-stable acoustic-trapping modes might be obtained using the model as a design tool.
机译:在微流体应用中,声阱用于捕获和处理悬浮的微粒和细胞。一种特别简单且经常使用的声阱包括由压电换能器驱动的市售毫米大小,充满液体的直玻璃毛细管。在这里,我们考虑到混合的驻波和行波以及吸收,给出了耦合到玻璃壁位移场的液体中声压场的三维数值模型。该模型解释了动力学机制,该动力学机制导致在这种直的声波导管中形成局部声共振模式,而在毛细管的轴向上没有任何几何空腔。该模型进一步预测这些模式中的某些模式非常适合于声捕获,并且可以提供它们的频率和品质因子,作为位置函数的单个测试粒子上的声辐射力的大小以及由此产生的声保持率的估计值。陷阱的力量。我们表明模型的预测与已发布的实验结果相符,并且我们讨论了如何使用模型作为设计工具来获得改进和更稳定的声陷模式。

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