首页> 外文OA文献 >Poor Invasion of Trophoblastic Cells but Normal Plaque Formation in Fibroblastic Cells despite actA Deletion in a Group of Listeria monocytogenes Strains Persisting in Some Food Processing Environments
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Poor Invasion of Trophoblastic Cells but Normal Plaque Formation in Fibroblastic Cells despite actA Deletion in a Group of Listeria monocytogenes Strains Persisting in Some Food Processing Environments

机译:尽管在一些食品加工环境中持续存在单核细胞增生李斯特菌菌株中的acta缺失,滋养层细胞对滋养层细胞的侵袭能力较差但在成纤维细胞中形成正常菌斑

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摘要

We determined mammalian cell invasion and virulence gene (inlA, inlB, and actA) sequences of Listeria monocytogenes strains belonging to a molecular subtype (RAPD 9) that often persists in Danish fish-processing plants. These strains invaded human placental trophoblasts less efficiently than other L. monocytogenes strains, including clinical strains, and they carry a premature stop codon in inlA. Eight of 15 strains, including the RAPD 9 and maternofetal strains, had a 105-nucleotide deletion in actA that did not affect cell-to-cell spread in mouse fibroblasts. The RAPD 9 strains may still be regarded as of low virulence with respect to human listeriosis.
机译:我们确定了属于分子亚型(RAPD 9)的李斯特菌单核细胞增生李斯特氏菌菌株的哺乳动物细胞侵袭和毒力基因(inlA,inlB和actA)序列,该序列通常在丹麦鱼类加工厂中持续存在。这些菌株侵袭人胎盘滋养细胞的效率比其他单核细胞增生李斯特氏菌菌株(包括临床菌株)低,并且它们在inlA中带有过早的终止密码子。 15个菌株中的8个,包括RAPD 9和母胎菌株,在actA中具有105个核苷酸的缺失,这并不影响小鼠成纤维细胞中的细胞间传播。相对于人类李斯特菌病,RAPD 9菌株仍被认为是低毒力的。

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