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Epinephrine improves 24-hour survival in a swine model of prolonged ventricular fibrillation demonstrating that early intraosseous is superior to delayed intravenous administration

机译:肾上腺素改善了长时间心室颤动的猪模型24小时存活率,证明早期骨内优于延迟静脉内给药

摘要

Vasopressors administered IV late during resuscitation efforts fail to improve survival. Intraosseous (IO) access can provide a route for earlier administration. We hypothesized that IO epinephrine after 1 minute of cardiopulmonary resuscitation (CPR) (an "optimal" IO scenario) after 10 minutes of untreated ventricular fibrillation (VF) cardiac arrest would improve outcome in comparison with either IV epinephrine after 8 minutes of CPR (a "realistic" IV scenario) or placebo controls with no epinephrine.
机译:在复苏过程中后期静脉输注血管加压药无法提高生存率。骨内(IO)访问可以为早期管理提供一条路径。我们假设,未经治疗的心室颤动(VF)心脏骤停10分钟后,进行心肺复苏(CPR)1分钟(“最佳” IO情境)后IO肾上腺素将比使用CPR 8分钟后的任一IV肾上腺素能改善预后。 “现实的” IV方案)或不含肾上腺素的安慰剂对照。

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