Functional neurology of a brain system: a 3D olfactory bulb model to process natural odorants

摘要

The network of interactions between mitral and granule cells in the olfactory bulb is a critical step in theudprocessing of odor information underlying the neural basis of smell perception. We are building the firstudcomputational model in 3 dimensions of this network in order to analyze the rules for connectivity and function within it. The initial results indicate that this network can be modeled to simulate experimental results on the udactivation of the olfactory bulb by natural odorants, udproviding a much more powerful approach for 3D simulation of brain neurons and microcircuits.