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Characterisation of a fibre optic Raman probe within a hypodermic needle.

机译:皮下注射针头内光纤拉曼探针的表征。

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摘要

We demonstrate the first use of a multifibre Raman probe that fits inside the bore of a hypodermic needle. A Raman probe containing multiple collection fibres provides improved signal collection efficiency in biological samples compared with a previous two-fibre design. Furthermore, probe performance (signal-to-noise ratios) compared favourably with the performance achieved in previous Raman microscope experiments able to distinguish between benign lymph nodes, primary malignancies in lymph nodes and secondary malignancies in lymph nodes. The experimental measurements presented here give an indication of the sampling volume of the Raman needle probe in lymphoid tissues. Liquid tissue phantoms were used that contained scattering medium encompassing a range of scattering properties similar to those of a variety of tissue types, including lymph node tissues. To validate the appropriateness of the phantoms, the sampling depth of the probe was also measured in excised lymph node tissue. More than 50 % of Raman photons collected were found to originate from between the tip of the needle and a depth of 500 μm into the tissue. The needle probe presented here achieves spectral quality comparable to that in numerous studies previously demonstrating Raman disease discrimination. It is expected that this approach could achieve targeted subcutaneous tissue measurements and be viable for use for the in vivo Raman diagnostics of solid organs located within a few centimetres below the skin's surface. Graphical Abstract Schematic of multi-fibre Raman needle probe with disposible tips and proximal optical filtration.
机译:我们演示了首次将多纤维拉曼探头安装在皮下注射针孔内。与先前的两根光纤设计相比,包含多根采集纤维的拉曼探针可提高生物样品中的信号采集效率。此外,探头性能(信噪比)与以前的拉曼显微镜实验所能达到的性能相比,后者能够区分良性淋巴结,淋巴结的原发性恶性肿瘤和淋巴结的继发性恶性肿瘤。此处介绍的实验测量结果可显示淋巴组织中拉曼针探针的采样量。使用的液体组织体模包含散射介质,该散射介质包含与一系列组织(包括淋巴结组织)相似的散射特性。为了验证体模的适当性,还在切除的淋巴结组织中测量了探头的采样深度。发现超过50%的拉曼光子起源于针尖和组织之间500μm的深度之间。此处提供的针头探针的光谱质量可与先前证明拉曼疾病鉴别的众多研究相媲美。预期该方法可以实现针对性的皮下组织测量,并且对于用于位于皮肤表面以下几厘米之内的实体器官的体内拉曼诊断是可行的。带有一次性尖端和近端光学过滤的多纤维拉曼针探针的图形摘要示意图。

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