A combination of motion-compensated cone-beam computed tomography image reconstruction and electrical impedance tomography

摘要

Cone-beam computed tomography (CBCT) is an imaging technique used in conjunction with radiation therapy. CBCT is used to verify the position of tumours just prior to radiation treatment session. The accuracy of the radiation treatment of thoracic and upper abdominal tumours is heavily affected by respiratory movement. Blurring artefacts, due to the movement during a CBCT scanning, cause misregistration between the CBCT image and the planning image. There has been growing interest in the use of motion-compensated CBCT for correcting the breathing-induced artefacts. A wide range of iterative reconstruction methods have been developed for CBCT imaging. The direct motion compensation technique has been applied to algebraic reconstruction technique (ART), simultaneous ART (SART), ordered-subset SART (OS-SART) and conjugate gradient least squares (CGLS). In this thesis a dual modality imaging of electrical impedance tomography (EIT) and CBCT is proposed for the first time. This novel dual modality imaging uses the advantages of high temporal resolution of EIT imaging and high spatial resolution of the CBCT method. The main objective of this study is to combine CBCT with EIT imaging system for motion-compensated CBCT using experimental and computational phantoms. The EIT images were used for extracting motion for a motion-compensated CBCT imaging system. A simple motion extraction technique is used for extracting motion data from the low spatial resolution EIT images. This motion data is suitable for input into the direct motion-compensated CBCT. The performance of iterative algorithms for motion compensation was also studied. The dual modality CBCT-EIT is verified using experimental EIT system and computational CBCT phantom data.